Cholinergic Neurotransmission in the Posterior Insular Cortex Is Altered in Preclinical Models of Neuropathic Pain: Key Role of Muscarinic M2 Receptors in Donepezil-Induced Antinociception

Neuropathic pain is one of the most debilitating pain conditions, yet no therapeutic strategy has been really effective for its treatment. Hence, a better understanding of its pathophysiological mechanisms is necessary to identify new pharmacological targets. Here, we report important metabolic vari...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of neuroscience 2015-12, Vol.35 (50), p.16418-16430
Hauptverfasser:	Ferrier, Jérémy, Bayet-Robert, Mathilde, Dalmann, Romain, El Guerrab, Abderrahim, Aissouni, Youssef, Graveron-Demilly, Danielle, Chalus, Maryse, Pinguet, Jérémy, Eschalier, Alain, Richard, Damien, Daulhac, Laurence, Marchand, Fabien, Balayssac, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - pharmacology Animals Cerebral Cortex - physiopathology Cholinesterase Inhibitors - pharmacology Donepezil Gene Expression - genetics Hyperalgesia - chemically induced Hyperalgesia - drug therapy Indans - pharmacology Interpersonal Relations Life Sciences Male Membrane Transport Proteins - metabolism Muscarinic Antagonists - pharmacology Neuralgia - chemically induced Neuralgia - physiopathology Neuralgia - psychology Neurobiology Neurons and Cognition Organoplatinum Compounds Oxaliplatin Parasympathetic Nervous System - physiopathology Pharmaceutical sciences Pharmacology Piperidines - pharmacology Rats Rats, Sprague-Dawley Receptor, Muscarinic M2 - drug effects Receptor, Muscarinic M2 - genetics RNA, Messenger - biosynthesis RNA, Messenger - genetics Synaptic Transmission
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!