Sleep duration, cognitive decline, and dementia risk in older women
Abstract Introduction Consistent evidence linking habitual sleep duration with risks of mild cognitive impairment (MCI) and dementia is lacking. Methods We conducted a prospective study on 7444 community-dwelling women (aged 65–80 y) with self-reported sleep duration, within the Women's Health...
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| Veröffentlicht in: | Alzheimer's & dementia 2016-01, Vol.12 (1), p.21-33 |
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| creator | Chen, Jiu-Chiuan Espeland, Mark A Brunner, Robert L Lovato, Laura C Wallace, Robert B Leng, Xiaoyan Phillips, Lawrence S Robinson, Jennifer G Kotchen, Jane M Johnson, Karen C Manson, JoAnn E Stefanick, Marcia L Sarto, Gloria E Mysiw, W. Jerry |
| description | Abstract Introduction Consistent evidence linking habitual sleep duration with risks of mild cognitive impairment (MCI) and dementia is lacking. Methods We conducted a prospective study on 7444 community-dwelling women (aged 65–80 y) with self-reported sleep duration, within the Women's Health Initiative Memory Study in 1995–2008. Incident MCI/dementia cases were ascertained by validated protocols. Cox models were used to adjust for multiple sociodemographic and lifestyle factors, depression, cardiovascular disease (CVD), and other clinical characteristics. Results We found a statistically significant ( P = .03) V-shaped association with a higher MCI/dementia risk in women with either short (≤6 hours/night) or long (≥8 hours/night) sleep duration (vs. 7 hours/night). The multicovariate-adjusted hazard for MCI/dementia was increased by 36% in short sleepers irrespective of CVD, and by 35% in long sleepers without CVD. A similar V-shaped association was found with cognitive decline. Discussion In older women, habitual sleep duration predicts the future risk for cognitive impairments including dementia, independent of vascular risk factors. |
| doi_str_mv | 10.1016/j.jalz.2015.03.004 |
| format | Article |
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Jerry</creator><creatorcontrib>Chen, Jiu-Chiuan ; Espeland, Mark A ; Brunner, Robert L ; Lovato, Laura C ; Wallace, Robert B ; Leng, Xiaoyan ; Phillips, Lawrence S ; Robinson, Jennifer G ; Kotchen, Jane M ; Johnson, Karen C ; Manson, JoAnn E ; Stefanick, Marcia L ; Sarto, Gloria E ; Mysiw, W. Jerry</creatorcontrib><description>Abstract Introduction Consistent evidence linking habitual sleep duration with risks of mild cognitive impairment (MCI) and dementia is lacking. Methods We conducted a prospective study on 7444 community-dwelling women (aged 65–80 y) with self-reported sleep duration, within the Women's Health Initiative Memory Study in 1995–2008. Incident MCI/dementia cases were ascertained by validated protocols. Cox models were used to adjust for multiple sociodemographic and lifestyle factors, depression, cardiovascular disease (CVD), and other clinical characteristics. Results We found a statistically significant ( P = .03) V-shaped association with a higher MCI/dementia risk in women with either short (≤6 hours/night) or long (≥8 hours/night) sleep duration (vs. 7 hours/night). The multicovariate-adjusted hazard for MCI/dementia was increased by 36% in short sleepers irrespective of CVD, and by 35% in long sleepers without CVD. A similar V-shaped association was found with cognitive decline. Discussion In older women, habitual sleep duration predicts the future risk for cognitive impairments including dementia, independent of vascular risk factors.</description><identifier>ISSN: 1552-5260</identifier><identifier>EISSN: 1552-5279</identifier><identifier>DOI: 10.1016/j.jalz.2015.03.004</identifier><identifier>PMID: 26086180</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Cognition ; Cognitive decline ; Cognitive Dysfunction - etiology ; Cohort studies ; Dementia ; Dementia - etiology ; Disorders of Excessive Somnolence - complications ; Elderly ; Female ; Humans ; Longitudinal analysis ; Mild cognitive impairment ; Neurology ; Proportional Hazards Models ; Prospective Studies ; Risk Factors ; Sleep ; Sleep duration ; Sleep Initiation and Maintenance Disorders - complications</subject><ispartof>Alzheimer's & dementia, 2016-01, Vol.12 (1), p.21-33</ispartof><rights>The Alzheimer's Association</rights><rights>2016 The Alzheimer's Association</rights><rights>Copyright © 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c7374-5620ab38d95c69b76198801104717b9eaca7133efb9599f3817213c2acec445d3</citedby><cites>FETCH-LOGICAL-c7374-5620ab38d95c69b76198801104717b9eaca7133efb9599f3817213c2acec445d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.jalz.2015.03.004$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.jalz.2015.03.004$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26086180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Jiu-Chiuan</creatorcontrib><creatorcontrib>Espeland, Mark A</creatorcontrib><creatorcontrib>Brunner, Robert L</creatorcontrib><creatorcontrib>Lovato, Laura C</creatorcontrib><creatorcontrib>Wallace, Robert B</creatorcontrib><creatorcontrib>Leng, Xiaoyan</creatorcontrib><creatorcontrib>Phillips, Lawrence S</creatorcontrib><creatorcontrib>Robinson, Jennifer G</creatorcontrib><creatorcontrib>Kotchen, Jane M</creatorcontrib><creatorcontrib>Johnson, Karen C</creatorcontrib><creatorcontrib>Manson, JoAnn E</creatorcontrib><creatorcontrib>Stefanick, Marcia L</creatorcontrib><creatorcontrib>Sarto, Gloria E</creatorcontrib><creatorcontrib>Mysiw, W. Jerry</creatorcontrib><title>Sleep duration, cognitive decline, and dementia risk in older women</title><title>Alzheimer's & dementia</title><addtitle>Alzheimers Dement</addtitle><description>Abstract Introduction Consistent evidence linking habitual sleep duration with risks of mild cognitive impairment (MCI) and dementia is lacking. Methods We conducted a prospective study on 7444 community-dwelling women (aged 65–80 y) with self-reported sleep duration, within the Women's Health Initiative Memory Study in 1995–2008. Incident MCI/dementia cases were ascertained by validated protocols. Cox models were used to adjust for multiple sociodemographic and lifestyle factors, depression, cardiovascular disease (CVD), and other clinical characteristics. Results We found a statistically significant ( P = .03) V-shaped association with a higher MCI/dementia risk in women with either short (≤6 hours/night) or long (≥8 hours/night) sleep duration (vs. 7 hours/night). The multicovariate-adjusted hazard for MCI/dementia was increased by 36% in short sleepers irrespective of CVD, and by 35% in long sleepers without CVD. A similar V-shaped association was found with cognitive decline. Discussion In older women, habitual sleep duration predicts the future risk for cognitive impairments including dementia, independent of vascular risk factors.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cognition</subject><subject>Cognitive decline</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Cohort studies</subject><subject>Dementia</subject><subject>Dementia - etiology</subject><subject>Disorders of Excessive Somnolence - complications</subject><subject>Elderly</subject><subject>Female</subject><subject>Humans</subject><subject>Longitudinal analysis</subject><subject>Mild cognitive impairment</subject><subject>Neurology</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Sleep</subject><subject>Sleep duration</subject><subject>Sleep Initiation and Maintenance Disorders - complications</subject><issn>1552-5260</issn><issn>1552-5279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk1v1DAQjRCIlsIf4IBy5NAN_ohjW0KVVqvyUa3EoXDhYjnObHHqtRc72Wr59TikrIAD6sX2jN-8efaboniJUYURbt70Va_dj4ogzCpEK4TqR8UpZowsGOHy8fHcoJPiWUp9BiCB2dPiJKdEgwU6LVbXDmBXdmPUgw3-vDThxtvB7qHswDjr4bzUvsvBFvxgdRltui2tL4PrIJZ3IaefF0822iV4cb-fFV_eXX5efVisP73_uFquF4ZTXi9YQ5BuqegkM41seYOlEAhjVHPMWwnaaI4phU0rmZQbKjAnmBqiDZi6Zh09Ky5m3t3YbqEzWVDUTu2i3ep4UEFb9feNt9_UTdiruuGSE5oJXt8TxPB9hDSorU0GnNMewpgU5o1goiaofggUCdEgLDOUzFATQ0oRNkdFGKnJKNWrySg1GaUQVegX_6s_33Is-e1MBixnwJ11cHgApVquv15d5WXKITo3eTtzQHZlbyGqZCx4A52NYAbVBft_jRf_lE8DYY12t3CA1Icx-uy3wioRhdT1NG7TtOX2-V-YoD8BK7_L8Q</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Chen, Jiu-Chiuan</creator><creator>Espeland, Mark A</creator><creator>Brunner, Robert L</creator><creator>Lovato, Laura C</creator><creator>Wallace, Robert B</creator><creator>Leng, Xiaoyan</creator><creator>Phillips, Lawrence S</creator><creator>Robinson, Jennifer G</creator><creator>Kotchen, Jane M</creator><creator>Johnson, Karen C</creator><creator>Manson, JoAnn E</creator><creator>Stefanick, Marcia L</creator><creator>Sarto, Gloria E</creator><creator>Mysiw, W. Jerry</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>201601</creationdate><title>Sleep duration, cognitive decline, and dementia risk in older women</title><author>Chen, Jiu-Chiuan ; Espeland, Mark A ; Brunner, Robert L ; Lovato, Laura C ; Wallace, Robert B ; Leng, Xiaoyan ; Phillips, Lawrence S ; Robinson, Jennifer G ; Kotchen, Jane M ; Johnson, Karen C ; Manson, JoAnn E ; Stefanick, Marcia L ; Sarto, Gloria E ; Mysiw, W. Jerry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c7374-5620ab38d95c69b76198801104717b9eaca7133efb9599f3817213c2acec445d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cognition</topic><topic>Cognitive decline</topic><topic>Cognitive Dysfunction - etiology</topic><topic>Cohort studies</topic><topic>Dementia</topic><topic>Dementia - etiology</topic><topic>Disorders of Excessive Somnolence - complications</topic><topic>Elderly</topic><topic>Female</topic><topic>Humans</topic><topic>Longitudinal analysis</topic><topic>Mild cognitive impairment</topic><topic>Neurology</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Sleep</topic><topic>Sleep duration</topic><topic>Sleep Initiation and Maintenance Disorders - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Jiu-Chiuan</creatorcontrib><creatorcontrib>Espeland, Mark A</creatorcontrib><creatorcontrib>Brunner, Robert L</creatorcontrib><creatorcontrib>Lovato, Laura C</creatorcontrib><creatorcontrib>Wallace, Robert B</creatorcontrib><creatorcontrib>Leng, Xiaoyan</creatorcontrib><creatorcontrib>Phillips, Lawrence S</creatorcontrib><creatorcontrib>Robinson, Jennifer G</creatorcontrib><creatorcontrib>Kotchen, Jane M</creatorcontrib><creatorcontrib>Johnson, Karen C</creatorcontrib><creatorcontrib>Manson, JoAnn E</creatorcontrib><creatorcontrib>Stefanick, Marcia L</creatorcontrib><creatorcontrib>Sarto, Gloria E</creatorcontrib><creatorcontrib>Mysiw, W. Jerry</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Alzheimer's & dementia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Jiu-Chiuan</au><au>Espeland, Mark A</au><au>Brunner, Robert L</au><au>Lovato, Laura C</au><au>Wallace, Robert B</au><au>Leng, Xiaoyan</au><au>Phillips, Lawrence S</au><au>Robinson, Jennifer G</au><au>Kotchen, Jane M</au><au>Johnson, Karen C</au><au>Manson, JoAnn E</au><au>Stefanick, Marcia L</au><au>Sarto, Gloria E</au><au>Mysiw, W. Jerry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sleep duration, cognitive decline, and dementia risk in older women</atitle><jtitle>Alzheimer's & dementia</jtitle><addtitle>Alzheimers Dement</addtitle><date>2016-01</date><risdate>2016</risdate><volume>12</volume><issue>1</issue><spage>21</spage><epage>33</epage><pages>21-33</pages><issn>1552-5260</issn><eissn>1552-5279</eissn><abstract>Abstract Introduction Consistent evidence linking habitual sleep duration with risks of mild cognitive impairment (MCI) and dementia is lacking. Methods We conducted a prospective study on 7444 community-dwelling women (aged 65–80 y) with self-reported sleep duration, within the Women's Health Initiative Memory Study in 1995–2008. Incident MCI/dementia cases were ascertained by validated protocols. Cox models were used to adjust for multiple sociodemographic and lifestyle factors, depression, cardiovascular disease (CVD), and other clinical characteristics. Results We found a statistically significant ( P = .03) V-shaped association with a higher MCI/dementia risk in women with either short (≤6 hours/night) or long (≥8 hours/night) sleep duration (vs. 7 hours/night). The multicovariate-adjusted hazard for MCI/dementia was increased by 36% in short sleepers irrespective of CVD, and by 35% in long sleepers without CVD. A similar V-shaped association was found with cognitive decline. Discussion In older women, habitual sleep duration predicts the future risk for cognitive impairments including dementia, independent of vascular risk factors.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26086180</pmid><doi>10.1016/j.jalz.2015.03.004</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Alzheimer's & dementia, 2016-01, Vol.12 (1), p.21-33 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Aged, 80 and over Cognition Cognitive decline Cognitive Dysfunction - etiology Cohort studies Dementia Dementia - etiology Disorders of Excessive Somnolence - complications Elderly Female Humans Longitudinal analysis Mild cognitive impairment Neurology Proportional Hazards Models Prospective Studies Risk Factors Sleep Sleep duration Sleep Initiation and Maintenance Disorders - complications |
| title | Sleep duration, cognitive decline, and dementia risk in older women |
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