Adolescent d-amphetamine treatment in a rodent model of ADHD: Pro-cognitive effects in adolescence without an impact on cocaine cue reactivity in adulthood

•Adolescent SHR exhibited set shift deficits compared to WKY and WIS controls.•Low dose d-amphetamine improved set shift performance only in adolescent SHR.•During adulthood, cocaine seeking and intake were greater in SHR than controls.•Adolescent d-amphetamine did not increase cocaine seeking or in...

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Veröffentlicht in:	Behavioural brain research 2016-01, Vol.297, p.165-179
Hauptverfasser:	Jordan, Chloe J., Taylor, Danielle M., Dwoskin, Linda P., Kantak, Kathleen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescence Aging - drug effects Amphetamine - pharmacology Animals Attention Deficit Disorder with Hyperactivity - drug therapy Attention Deficit Disorder with Hyperactivity - physiopathology Attention deficit/hyperactivity disorder Central Nervous System Stimulants - pharmacology Choice Behavior - drug effects Choice Behavior - physiology Cocaine - administration & dosage Cocaine cue reactivity Cocaine-Related Disorders - physiopathology Cues d-Amphetamine Disease Models, Animal Dopamine Uptake Inhibitors - administration & dosage Male Psychotropic Drugs - pharmacology Rats, Inbred SHR Rats, Inbred WKY Rats, Wistar Self Administration Spontaneously Hypertensive Rat Strategy set shifting task
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