CD4 T Cells but Not Th17 Cells Are Required for Mouse Lung Transplant Obliterative Bronchiolitis

Lung transplant survival is limited by obliterative bronchiolitis (OB), but the mechanisms of OB development are unknown. Previous studies in a mouse model of orthotopic lung transplantation suggested a requirement for IL‐17. We have used this orthotopic mouse model to investigate the source of IL‐1...

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Veröffentlicht in:	American journal of transplantation 2015-07, Vol.15 (7), p.1793-1804
Hauptverfasser:	Wu, Q., Gupta, P. K., Suzuki, H., Wagner, S. R., Zhang, C., Cummings, O. W., Fan, L., Kaplan, M. H., Wilkes, D. S., Shilling, R. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models: murine Animals basic (laboratory) research/science biology bronchiolitis obliterans (BOS) Bronchiolitis Obliterans - immunology Bronchiolitis Obliterans - metabolism CD4-Positive T-Lymphocytes - immunology Disease Models, Animal Flow Cytometry Graft Survival - immunology immunobiology Interferon-gamma - metabolism Interleukin-17 - immunology lung (allograft) function/dysfunction Lung Transplantation lung transplantation/pulmonology Lymphocyte Depletion Lymphocytes Mice Mice, Inbred C57BL Mice, Knockout Rodents STAT3 Transcription Factor - physiology T cell Th17 Cells - immunology Transplants & implants
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