A YAP/TAZ-miR-130/301 molecular circuit exerts systems-level control of fibrosis in a network of human diseases and physiologic conditions

The molecular origins of fibrosis affecting multiple tissue beds remain incompletely defined. Previously, we delineated the critical role of the control of extracellular matrix (ECM) stiffening by the mechanosensitive microRNA-130/301 family, as activated by the YAP/TAZ co-transcription factors, in...

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Veröffentlicht in:	Scientific reports 2015-12, Vol.5 (1), p.18277-18277, Article 18277
Hauptverfasser:	Bertero, Thomas, Cottrill, Katherine A., Annis, Sofia, Bhat, Balkrishen, Gochuico, Bernadette R., Osorio, Juan C., Rosas, Ivan, Haley, Kathleen J., Corey, Kathleen E., Chung, Raymond T., Nelson Chau, B., Chan, Stephen Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 38/39 38/89 38/90 42 49 59 631/337/384/331 631/80/304 64/60 692/699 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Apolipoproteins E - genetics Apolipoproteins E - metabolism Benzoates - pharmacology Benzylamines - pharmacology Disease Models, Animal Extracellular Matrix Feedback Fibrosis Gene Expression Regulation Gene Regulatory Networks Humanities and Social Sciences Humans Hypertension Hypertension, Pulmonary - genetics Hypertension, Pulmonary - metabolism Hypertension, Pulmonary - pathology Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism LDL-Receptor Related Proteins - genetics LDL-Receptor Related Proteins - metabolism Liver Liver Cirrhosis - genetics Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Lung diseases Mice MicroRNAs MicroRNAs - genetics miRNA multidisciplinary Phosphoproteins - genetics Phosphoproteins - metabolism Pulmonary Fibrosis - genetics Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Science Trans-Activators Transcription Factors Transcriptional Coactivator with PDZ-Binding Motif Proteins YAP-Signaling Proteins Yes-associated protein
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