Regiospecific Hetero-Assembly of DNA-Functionalized Plasmonic Upconversion Superstructures
We report a novel strategy for regiospecific hetero-assembly of DNA-modified gold nanoparticles (DNA-AuNPs) onto upconversion nanoparticles (UCNPs) into hybrid lab-on-a-particle systems. The DNA-AuNPs have been assembled onto the hexagonal plate-like UCNPs with well-regulated stoichiometry and contr...
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| Veröffentlicht in: | Journal of the American Chemical Society 2015-04, Vol.137 (16), p.5272-5275 |
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| container_title | Journal of the American Chemical Society |
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| creator | Li, Le-Le Lu, Yi |
| description | We report a novel strategy for regiospecific hetero-assembly of DNA-modified gold nanoparticles (DNA-AuNPs) onto upconversion nanoparticles (UCNPs) into hybrid lab-on-a-particle systems. The DNA-AuNPs have been assembled onto the hexagonal plate-like UCNPs with well-regulated stoichiometry and controlled organization onto the different facets of UCNP, forming various addressable superstructures. The fine-tuning of stoichiometry and organization is realized by biorecognition specificity of DNA toward specific crystal facets of UCNPs. Such a hetero-assembled DNA-AuNP/UCNP system maintains both plasmonic resonance of AuNPs and fluorescent properties of UCNPs, allowing targeted dual-modality imaging of cancer cells using an aptamer. |
| doi_str_mv | 10.1021/jacs.5b01092 |
| format | Article |
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Am. Chem. Soc</addtitle><description>We report a novel strategy for regiospecific hetero-assembly of DNA-modified gold nanoparticles (DNA-AuNPs) onto upconversion nanoparticles (UCNPs) into hybrid lab-on-a-particle systems. The DNA-AuNPs have been assembled onto the hexagonal plate-like UCNPs with well-regulated stoichiometry and controlled organization onto the different facets of UCNP, forming various addressable superstructures. The fine-tuning of stoichiometry and organization is realized by biorecognition specificity of DNA toward specific crystal facets of UCNPs. Such a hetero-assembled DNA-AuNP/UCNP system maintains both plasmonic resonance of AuNPs and fluorescent properties of UCNPs, allowing targeted dual-modality imaging of cancer cells using an aptamer.</description><subject>Animals</subject><subject>Aptamers, Nucleotide - chemistry</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Cell Line, Tumor</subject><subject>Communication</subject><subject>Crystals</subject><subject>DNA - chemistry</subject><subject>Female</subject><subject>fluorescence</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Gold - chemistry</subject><subject>image analysis</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metal Nanoparticles - ultrastructure</subject><subject>Mice</subject><subject>nanogold</subject><subject>Nanoparticles</subject><subject>neoplasm cells</subject><subject>neoplasms</subject><subject>Nucleolin</subject><subject>oligonucleotides</subject><subject>Optical Imaging</subject><subject>Organizations</subject><subject>Phosphoproteins - analysis</subject><subject>Plasmonics</subject><subject>RNA-Binding Proteins - analysis</subject><subject>Stereoisomerism</subject><subject>Stoichiometry</subject><subject>Strategy</subject><subject>Superstructures</subject><subject>Upconversion</subject><issn>0002-7863</issn><issn>1520-5126</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>N~.</sourceid><sourceid>EIF</sourceid><recordid>eNqFkUtP3DAURq0KVAbaXdcoSxYEfB2_ZlNpRHlJCKq2bLqxHNuhHiVxaidI8OvxwECLhMTKtu7x8b3-EPoC-AAwgcOlNumA1RjwnHxAM2AElwwI30AzjDEpheTVFtpOaZmPlEj4iLYIk6xinM3Q7x_uxoc0OOMbb4ozN7oYykVKrqvbuyI0xbfLRXky9Wb0odetv3e2-N7q1IU-89eDCf2tiykXi5_TkHdjnMw4RZc-oc1Gt8l9Xq876Prk-NfRWXlxdXp-tLgoNQM-lqLBdV0LQ4yljTWiIZwZzi2ljGLZSMY0M5YQmDNhrQVC84TEcgkGwNW22kFfn7zDVHfOGtePUbdqiL7T8U4F7dXrSu__qJtwqygXgvMqC_bWghj-Ti6NqvPJuLbVvQtTUiR_XCVoJcW7KEgsAWCete-iYk4Zhuqxgf0n1MSQUnTNS_OA1SpktQpZrUPO-O7_A7_Az6n-e3p1axmmmINLb7seACvpsaA</recordid><startdate>20150429</startdate><enddate>20150429</enddate><creator>Li, Le-Le</creator><creator>Lu, Yi</creator><general>American Chemical Society</general><scope>N~.</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20150429</creationdate><title>Regiospecific Hetero-Assembly of DNA-Functionalized Plasmonic Upconversion Superstructures</title><author>Li, Le-Le ; Lu, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a516t-7f0bbb7c2cd4fdc7f265c66d445408f855a5cd221957ddd1245202d681c11ebd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Aptamers, Nucleotide - chemistry</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Cell Line, Tumor</topic><topic>Communication</topic><topic>Crystals</topic><topic>DNA - chemistry</topic><topic>Female</topic><topic>fluorescence</topic><topic>Fluorescent Dyes - chemistry</topic><topic>Gold - chemistry</topic><topic>image analysis</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Metal Nanoparticles - ultrastructure</topic><topic>Mice</topic><topic>nanogold</topic><topic>Nanoparticles</topic><topic>neoplasm cells</topic><topic>neoplasms</topic><topic>Nucleolin</topic><topic>oligonucleotides</topic><topic>Optical Imaging</topic><topic>Organizations</topic><topic>Phosphoproteins - analysis</topic><topic>Plasmonics</topic><topic>RNA-Binding Proteins - analysis</topic><topic>Stereoisomerism</topic><topic>Stoichiometry</topic><topic>Strategy</topic><topic>Superstructures</topic><topic>Upconversion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Le-Le</creatorcontrib><creatorcontrib>Lu, Yi</creatorcontrib><collection>American Chemical Society (ACS) Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Le-Le</au><au>Lu, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regiospecific Hetero-Assembly of DNA-Functionalized Plasmonic Upconversion Superstructures</atitle><jtitle>Journal of the American Chemical Society</jtitle><addtitle>J. Am. Chem. Soc</addtitle><date>2015-04-29</date><risdate>2015</risdate><volume>137</volume><issue>16</issue><spage>5272</spage><epage>5275</epage><pages>5272-5275</pages><issn>0002-7863</issn><issn>1520-5126</issn><eissn>1520-5126</eissn><abstract>We report a novel strategy for regiospecific hetero-assembly of DNA-modified gold nanoparticles (DNA-AuNPs) onto upconversion nanoparticles (UCNPs) into hybrid lab-on-a-particle systems. The DNA-AuNPs have been assembled onto the hexagonal plate-like UCNPs with well-regulated stoichiometry and controlled organization onto the different facets of UCNP, forming various addressable superstructures. The fine-tuning of stoichiometry and organization is realized by biorecognition specificity of DNA toward specific crystal facets of UCNPs. 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| source | ACS Publications; MEDLINE |
| subjects | Animals Aptamers, Nucleotide - chemistry Breast Neoplasms - diagnosis Cell Line, Tumor Communication Crystals DNA - chemistry Female fluorescence Fluorescent Dyes - chemistry Gold - chemistry image analysis Metal Nanoparticles - chemistry Metal Nanoparticles - ultrastructure Mice nanogold Nanoparticles neoplasm cells neoplasms Nucleolin oligonucleotides Optical Imaging Organizations Phosphoproteins - analysis Plasmonics RNA-Binding Proteins - analysis Stereoisomerism Stoichiometry Strategy Superstructures Upconversion |
| title | Regiospecific Hetero-Assembly of DNA-Functionalized Plasmonic Upconversion Superstructures |
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