Crosstalk with cancer-associated fibroblasts induces resistance of non-small cell lung cancer cells to epidermal growth factor receptor tyrosine kinase inhibition

Although lung cancers with activating mutations in the epidermal growth factor receptor (EGFR) are highly sensitive to selective EGFR tyrosine kinase inhibitors (TKIs), these tumors invariably develop acquired drug resistance. Host stromal cells have been found to have a considerable effect on the s...

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Veröffentlicht in:	OncoTargets and therapy 2015-01, Vol.8, p.3665-3678
Hauptverfasser:	Choe, Chungyoul, Shin, Yong-Sung, Kim, Changhoon, Choi, So-Jung, Lee, Jinseon, Kim, So Young, Cho, Yong Beom, Kim, Jhingook
Format:	Artikel
Sprache:	eng
Schlagworte:	Cellular signal transduction Drug resistance Enzyme inhibitors Hedgehog proteins Lung cancer, Non-small cell Observations Original Research Properties Testing
Online-Zugang:	Volltext
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