Evidence that a neutrophil-keratinocyte crosstalk is an early target of IL-17A inhibition in psoriasis

The response of psoriasis to antibodies targeting the interleukin (IL)‐23/IL‐17A pathway suggests a prominent role of T‐helper type‐17 (Th17) cells in this disease. We examined the clinical and immunological response patterns of 100 subjects with moderate‐to‐severe psoriasis receiving 3 different in...

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Veröffentlicht in:	Experimental dermatology 2015-07, Vol.24 (7), p.529-535
Hauptverfasser:	Reich, Kristian, Papp, Kim A., Matheson, Robert T., Tu, John H., Bissonnette, Robert, Bourcier, Marc, Gratton, David, Kunynetz, Rodion A., Poulin, Yves, Rosoph, Les A., Stingl, Georg, Bauer, Wolfgang M., Salter, Janeen M., Falk, Thomas M., Blödorn-Schlicht, Norbert A., Hueber, Wolfgang, Sommer, Ulrike, Schumacher, Martin M., Peters, Thomas, Kriehuber, Ernst, Lee, David M., Wieczorek, Grazyna A., Kolbinger, Frank, Bleul, Conrad C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Cell Communication - immunology Dose-Response Relationship, Immunologic Humans IL-17A Interleukin-17 - antagonists & inhibitors Keratinocytes - immunology Keratinocytes - pathology Middle Aged neutrophils Neutrophils - immunology Neutrophils - pathology Original psoriasis Psoriasis - immunology Psoriasis - pathology Psoriasis - therapy secukinumab Time Factors Young Adult
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