IFN-γ modulates Ly-49 receptors on NK cells in IFN-γ-induced pregnancy failure

We have previously shown that interferon gamma (IFN-γ) induces aberrant CD49b + natural killer (NK) cell recruitment by regulating CX3CL1 and eventually provokes foetal loss. In this study, we show that IFN-γ also modulates Ly-49 receptors on NK cells during pregnancy failure. The percentages of Ly-...

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Veröffentlicht in:	Scientific reports 2015-12, Vol.5 (1), p.18159-18159, Article 18159
Hauptverfasser:	Li, Zhong-Yin, Song, Zhi-Hui, Meng, Chao-Yang, Yang, Dan-Dan, Yang, Ying, Peng, Jing-Pian
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 631/136/1425 631/250/2504 Abortion, Induced Animals Antigens, Ly - metabolism Cells, Cultured CX3C Chemokine Receptor 1 Female Flow Cytometry Gene Expression - drug effects Humanities and Social Sciences Interferon-gamma - pharmacology Killer Cells, Natural - drug effects Killer Cells, Natural - metabolism Leukocytes - drug effects Leukocytes - metabolism Male Mice, Inbred BALB C multidisciplinary Pregnancy Pregnancy Outcome Receptors, Chemokine - genetics Receptors, Chemokine - metabolism Receptors, Immunologic - metabolism Reverse Transcriptase Polymerase Chain Reaction Science Spleen - cytology
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