Integrin Molecular Tension within Motile Focal Adhesions

Forces transmitted by integrins regulate many important cellular functions. Previously, we developed tension gauge tether (TGT) as a molecular force sensor and determined the threshold tension across a single integrin-ligand bond, termed integrin tension, required for initial cell adhesion. Here, we...

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Veröffentlicht in:	Biophysical journal 2015-12, Vol.109 (11), p.2259-2267
Hauptverfasser:	Wang, Xuefeng, Sun, Jie, Xu, Qian, Chowdhury, Farhan, Roein-Peikar, Mehdi, Wang, Yingxiao, Ha, Taekjip
Format:	Artikel
Sprache:	eng
Schlagworte:	Actomyosin - metabolism Animals Base Sequence Biological Transport Biomechanical Phenomena Cell Adhesion Cell adhesion & migration Cell Biophysics CHO Cells Cricetinae Cricetulus DNA, Single-Stranded - genetics DNA, Single-Stranded - metabolism Fluorescence Fluorescent Dyes - metabolism Focal Adhesions - metabolism Immobilized Proteins - metabolism Integrins - metabolism Ligands Mechanical Phenomena Molecules Tension
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