β-Catenin is required for intrinsic but not extrinsic BCR-ABL1 kinase-independent resistance to tyrosine kinase inhibitors in chronic myeloid leukemia

Activation of nuclear β-catenin and expression of its transcriptional targets promotes chronic myeloid leukemia (CML) progression, tyrosine kinase inhibitor (TKI) resistance, and leukemic stem cell self-renewal. We report that nuclear β-catenin has a role in leukemia cell-intrinsic but not -extrinsi...

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Veröffentlicht in:	Leukemia 2015-12, Vol.29 (12), p.2328-2337
Hauptverfasser:	Eiring, A M, Khorashad, J S, Anderson, D J, Yu, F, Redwine, H M, Mason, C C, Reynolds, K R, Clair, P M, Gantz, K C, Zhang, T Y, Pomicter, A D, Kraft, I L, Bowler, A D, Johnson, K, Partlin, M Mac, O'Hare, T, Deininger, M W
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/31 13/44 45/90 631/67/1990/283/1896 631/67/395 631/80/86 692/699/67/1059/2326 692/699/67/327 96/109 Antibodies beta Catenin - physiology Blocking antibodies Bone marrow Cadherins Cadherins - physiology Cancer Research Cell adhesion molecules Cell culture Cell Line, Tumor Cell self-renewal Chronic myeloid leukemia Critical Care Medicine Development and progression Dosage and administration Drug resistance Drug Resistance, Neoplasm Drug therapy Enzyme inhibitors Fusion Proteins, bcr-abl - physiology Gene expression Genetic aspects Health aspects Hematology Humans Imatinib Imatinib Mesylate - therapeutic use Intensive Internal Medicine Kinases LEF protein Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Medicine Medicine & Public Health Myeloid leukemia N-Cadherin Oncology original-article Protein Kinase Inhibitors - therapeutic use Protein-Tyrosine Kinases - antagonists & inhibitors Proto-Oncogene Proteins - physiology Stem cells Stromal cells Suspension culture Transcription Tyrosine Tyrosine kinase inhibitors Wnt Proteins - physiology Wnt-5a Protein β-Catenin
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