Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors
Recent successes in treating genetic immunodeficiencies have demonstrated the therapeutic potential of stem cell gene therapy. However, the use of gammaretroviral vectors in these trials led to insertional activation of nearby oncogenes and leukemias in some study subjects, prompting studies of modi...
Gespeichert in:
| Veröffentlicht in: | Nature medicine 2008-01, Vol.14 (1), p.93-97 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 97 |
|---|---|
| container_issue | 1 |
| container_start_page | 93 |
| container_title | Nature medicine |
| container_volume | 14 |
| creator | Russell, David W Hickstein, Dennis D Bauer, Thomas R Allen, James M Hai, Mehreen Tuschong, Laura M Khan, Iram F Olson, Erik M Adler, Rima L Burkholder, Tanya H Gu, Yu-chen |
| description | Recent successes in treating genetic immunodeficiencies have demonstrated the therapeutic potential of stem cell gene therapy. However, the use of gammaretroviral vectors in these trials led to insertional activation of nearby oncogenes and leukemias in some study subjects, prompting studies of modified or alternative vector systems. Here we describe the use of foamy virus vectors to treat canine leukocyte adhesion deficiency (CLAD). Four of five dogs with CLAD that received nonmyeloablative conditioning and infusion of autologous, CD34+ hematopoietic stem cells transduced by a foamy virus vector expressing canine CD18 had complete reversal of the CLAD phenotype, which was sustained more than 2 years after infusion. In vitro assays showed correction of the lymphocyte proliferation and neutrophil adhesion defects that characterize CLAD. There were no genotoxic complications, and integration site analysis showed polyclonality of transduced cells and a decreased risk of integration near oncogenes as compared to gammaretroviral vectors. These results represent the first successful use of a foamy virus vector to treat a genetic disease, to our knowledge, and suggest that foamy virus vectors will be effective in treating human hematopoietic diseases. |
| doi_str_mv | 10.1038/nm1695 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4675671</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A192447741</galeid><sourcerecordid>A192447741</sourcerecordid><originalsourceid>FETCH-LOGICAL-c683t-7d0d4fa3940924775d86e3cab107258c2f9c07f135ce078a2a02b9101413766e3</originalsourceid><addsrcrecordid>eNqNkl1rFDEUhgdRbF31F4gMXlS8mJqPyWTmRijFj0Kh4Kp4F7KZM7OpM0mbj8X592bZpdvVRSUXCTnPeTnvOSfLnmN0ihGt35oRVw17kB1jVlYF5uj7w_RGvC7qhlVH2RPvrxFCFLHmcXaEa8w4pvVxNp9HpcD7Lg55cCDDCCbktsuVNNpAPkD8YdUUIJftEry2Jm-h00qDUVO-mPLOynHKV9pFn69ABev80-xRJwcPz7b3LPv64f2X80_F5dXHi_Ozy0JVNQ0Fb1FbdpI2JWpIyTlr6wqokotUNmG1Il2jEO8wZQqSEUkkIosGI1xiyquEzrJ3G92buBihValyJwdx4_Qo3SSs1GI_YvRS9HYlyoqzKvmfZa-3As7eRvBBjNorGAZpwEYvOGsoZqxiiTz5O4lwTQkv_wkSVJeUkDX46jfw2kZnUr8EIRRjWpU8QcUG6uUAQpvOJh-qBwPJjjVpEOn7DKf2pf6Va0OnB_h0Whi1OpjwZi8hMQF-hl5G78XF_PP_s1ff9tmTe-wS5BCW3g4xpAXyB0HlrPcOurvxYSTWmy02m53Al_eHvcO2q7wbpk8h04PbNfQPqRcb0sgQHdxJbcO_AL4dBtw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223113647</pqid></control><display><type>article</type><title>Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors</title><source>MEDLINE</source><source>Nature</source><source>Alma/SFX Local Collection</source><creator>Russell, David W ; Hickstein, Dennis D ; Bauer, Thomas R ; Allen, James M ; Hai, Mehreen ; Tuschong, Laura M ; Khan, Iram F ; Olson, Erik M ; Adler, Rima L ; Burkholder, Tanya H ; Gu, Yu-chen</creator><creatorcontrib>Russell, David W ; Hickstein, Dennis D ; Bauer, Thomas R ; Allen, James M ; Hai, Mehreen ; Tuschong, Laura M ; Khan, Iram F ; Olson, Erik M ; Adler, Rima L ; Burkholder, Tanya H ; Gu, Yu-chen</creatorcontrib><description>Recent successes in treating genetic immunodeficiencies have demonstrated the therapeutic potential of stem cell gene therapy. However, the use of gammaretroviral vectors in these trials led to insertional activation of nearby oncogenes and leukemias in some study subjects, prompting studies of modified or alternative vector systems. Here we describe the use of foamy virus vectors to treat canine leukocyte adhesion deficiency (CLAD). Four of five dogs with CLAD that received nonmyeloablative conditioning and infusion of autologous, CD34+ hematopoietic stem cells transduced by a foamy virus vector expressing canine CD18 had complete reversal of the CLAD phenotype, which was sustained more than 2 years after infusion. In vitro assays showed correction of the lymphocyte proliferation and neutrophil adhesion defects that characterize CLAD. There were no genotoxic complications, and integration site analysis showed polyclonality of transduced cells and a decreased risk of integration near oncogenes as compared to gammaretroviral vectors. These results represent the first successful use of a foamy virus vector to treat a genetic disease, to our knowledge, and suggest that foamy virus vectors will be effective in treating human hematopoietic diseases.</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/nm1695</identifier><identifier>PMID: 18157138</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Adhesion ; Animals ; Antigens, CD34 - biosynthesis ; Biomedical and Life Sciences ; Biomedicine ; Bone Marrow Cells - metabolism ; Cancer Research ; Care and treatment ; Cell Adhesion ; Cell Proliferation ; Dogs ; Foamy virus ; Gene mutations ; Gene therapy ; Genetic aspects ; Genetic Therapy - methods ; Genetic Vectors ; Genetics ; Health aspects ; Hematopoietic Stem Cells - metabolism ; Immunodeficiency ; Infectious Diseases ; letter ; Leukocyte disorders ; Leukocyte-Adhesion Deficiency Syndrome - genetics ; Leukocyte-Adhesion Deficiency Syndrome - therapy ; Leukocyte-Adhesion Deficiency Syndrome - veterinary ; Leukocytes ; Leukocytes - cytology ; Lymphocytes ; Lymphocytes - metabolism ; Medical treatment ; Metabolic Diseases ; Molecular Medicine ; Neurosciences ; Phenotype ; Spumavirus - genetics ; Stem cells ; Viruses</subject><ispartof>Nature medicine, 2008-01, Vol.14 (1), p.93-97</ispartof><rights>Springer Nature America, Inc. 2008</rights><rights>COPYRIGHT 2008 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c683t-7d0d4fa3940924775d86e3cab107258c2f9c07f135ce078a2a02b9101413766e3</citedby><cites>FETCH-LOGICAL-c683t-7d0d4fa3940924775d86e3cab107258c2f9c07f135ce078a2a02b9101413766e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18157138$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Russell, David W</creatorcontrib><creatorcontrib>Hickstein, Dennis D</creatorcontrib><creatorcontrib>Bauer, Thomas R</creatorcontrib><creatorcontrib>Allen, James M</creatorcontrib><creatorcontrib>Hai, Mehreen</creatorcontrib><creatorcontrib>Tuschong, Laura M</creatorcontrib><creatorcontrib>Khan, Iram F</creatorcontrib><creatorcontrib>Olson, Erik M</creatorcontrib><creatorcontrib>Adler, Rima L</creatorcontrib><creatorcontrib>Burkholder, Tanya H</creatorcontrib><creatorcontrib>Gu, Yu-chen</creatorcontrib><title>Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors</title><title>Nature medicine</title><addtitle>Nat Med</addtitle><addtitle>Nat Med</addtitle><description>Recent successes in treating genetic immunodeficiencies have demonstrated the therapeutic potential of stem cell gene therapy. However, the use of gammaretroviral vectors in these trials led to insertional activation of nearby oncogenes and leukemias in some study subjects, prompting studies of modified or alternative vector systems. Here we describe the use of foamy virus vectors to treat canine leukocyte adhesion deficiency (CLAD). Four of five dogs with CLAD that received nonmyeloablative conditioning and infusion of autologous, CD34+ hematopoietic stem cells transduced by a foamy virus vector expressing canine CD18 had complete reversal of the CLAD phenotype, which was sustained more than 2 years after infusion. In vitro assays showed correction of the lymphocyte proliferation and neutrophil adhesion defects that characterize CLAD. There were no genotoxic complications, and integration site analysis showed polyclonality of transduced cells and a decreased risk of integration near oncogenes as compared to gammaretroviral vectors. These results represent the first successful use of a foamy virus vector to treat a genetic disease, to our knowledge, and suggest that foamy virus vectors will be effective in treating human hematopoietic diseases.</description><subject>Adhesion</subject><subject>Animals</subject><subject>Antigens, CD34 - biosynthesis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bone Marrow Cells - metabolism</subject><subject>Cancer Research</subject><subject>Care and treatment</subject><subject>Cell Adhesion</subject><subject>Cell Proliferation</subject><subject>Dogs</subject><subject>Foamy virus</subject><subject>Gene mutations</subject><subject>Gene therapy</subject><subject>Genetic aspects</subject><subject>Genetic Therapy - methods</subject><subject>Genetic Vectors</subject><subject>Genetics</subject><subject>Health aspects</subject><subject>Hematopoietic Stem Cells - metabolism</subject><subject>Immunodeficiency</subject><subject>Infectious Diseases</subject><subject>letter</subject><subject>Leukocyte disorders</subject><subject>Leukocyte-Adhesion Deficiency Syndrome - genetics</subject><subject>Leukocyte-Adhesion Deficiency Syndrome - therapy</subject><subject>Leukocyte-Adhesion Deficiency Syndrome - veterinary</subject><subject>Leukocytes</subject><subject>Leukocytes - cytology</subject><subject>Lymphocytes</subject><subject>Lymphocytes - metabolism</subject><subject>Medical treatment</subject><subject>Metabolic Diseases</subject><subject>Molecular Medicine</subject><subject>Neurosciences</subject><subject>Phenotype</subject><subject>Spumavirus - genetics</subject><subject>Stem cells</subject><subject>Viruses</subject><issn>1078-8956</issn><issn>1546-170X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkl1rFDEUhgdRbF31F4gMXlS8mJqPyWTmRijFj0Kh4Kp4F7KZM7OpM0mbj8X592bZpdvVRSUXCTnPeTnvOSfLnmN0ihGt35oRVw17kB1jVlYF5uj7w_RGvC7qhlVH2RPvrxFCFLHmcXaEa8w4pvVxNp9HpcD7Lg55cCDDCCbktsuVNNpAPkD8YdUUIJftEry2Jm-h00qDUVO-mPLOynHKV9pFn69ABev80-xRJwcPz7b3LPv64f2X80_F5dXHi_Ozy0JVNQ0Fb1FbdpI2JWpIyTlr6wqokotUNmG1Il2jEO8wZQqSEUkkIosGI1xiyquEzrJ3G92buBihValyJwdx4_Qo3SSs1GI_YvRS9HYlyoqzKvmfZa-3As7eRvBBjNorGAZpwEYvOGsoZqxiiTz5O4lwTQkv_wkSVJeUkDX46jfw2kZnUr8EIRRjWpU8QcUG6uUAQpvOJh-qBwPJjjVpEOn7DKf2pf6Va0OnB_h0Whi1OpjwZi8hMQF-hl5G78XF_PP_s1ff9tmTe-wS5BCW3g4xpAXyB0HlrPcOurvxYSTWmy02m53Al_eHvcO2q7wbpk8h04PbNfQPqRcb0sgQHdxJbcO_AL4dBtw</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Russell, David W</creator><creator>Hickstein, Dennis D</creator><creator>Bauer, Thomas R</creator><creator>Allen, James M</creator><creator>Hai, Mehreen</creator><creator>Tuschong, Laura M</creator><creator>Khan, Iram F</creator><creator>Olson, Erik M</creator><creator>Adler, Rima L</creator><creator>Burkholder, Tanya H</creator><creator>Gu, Yu-chen</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7QO</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080101</creationdate><title>Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors</title><author>Russell, David W ; Hickstein, Dennis D ; Bauer, Thomas R ; Allen, James M ; Hai, Mehreen ; Tuschong, Laura M ; Khan, Iram F ; Olson, Erik M ; Adler, Rima L ; Burkholder, Tanya H ; Gu, Yu-chen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c683t-7d0d4fa3940924775d86e3cab107258c2f9c07f135ce078a2a02b9101413766e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adhesion</topic><topic>Animals</topic><topic>Antigens, CD34 - biosynthesis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bone Marrow Cells - metabolism</topic><topic>Cancer Research</topic><topic>Care and treatment</topic><topic>Cell Adhesion</topic><topic>Cell Proliferation</topic><topic>Dogs</topic><topic>Foamy virus</topic><topic>Gene mutations</topic><topic>Gene therapy</topic><topic>Genetic aspects</topic><topic>Genetic Therapy - methods</topic><topic>Genetic Vectors</topic><topic>Genetics</topic><topic>Health aspects</topic><topic>Hematopoietic Stem Cells - metabolism</topic><topic>Immunodeficiency</topic><topic>Infectious Diseases</topic><topic>letter</topic><topic>Leukocyte disorders</topic><topic>Leukocyte-Adhesion Deficiency Syndrome - genetics</topic><topic>Leukocyte-Adhesion Deficiency Syndrome - therapy</topic><topic>Leukocyte-Adhesion Deficiency Syndrome - veterinary</topic><topic>Leukocytes</topic><topic>Leukocytes - cytology</topic><topic>Lymphocytes</topic><topic>Lymphocytes - metabolism</topic><topic>Medical treatment</topic><topic>Metabolic Diseases</topic><topic>Molecular Medicine</topic><topic>Neurosciences</topic><topic>Phenotype</topic><topic>Spumavirus - genetics</topic><topic>Stem cells</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Russell, David W</creatorcontrib><creatorcontrib>Hickstein, Dennis D</creatorcontrib><creatorcontrib>Bauer, Thomas R</creatorcontrib><creatorcontrib>Allen, James M</creatorcontrib><creatorcontrib>Hai, Mehreen</creatorcontrib><creatorcontrib>Tuschong, Laura M</creatorcontrib><creatorcontrib>Khan, Iram F</creatorcontrib><creatorcontrib>Olson, Erik M</creatorcontrib><creatorcontrib>Adler, Rima L</creatorcontrib><creatorcontrib>Burkholder, Tanya H</creatorcontrib><creatorcontrib>Gu, Yu-chen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Russell, David W</au><au>Hickstein, Dennis D</au><au>Bauer, Thomas R</au><au>Allen, James M</au><au>Hai, Mehreen</au><au>Tuschong, Laura M</au><au>Khan, Iram F</au><au>Olson, Erik M</au><au>Adler, Rima L</au><au>Burkholder, Tanya H</au><au>Gu, Yu-chen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors</atitle><jtitle>Nature medicine</jtitle><stitle>Nat Med</stitle><addtitle>Nat Med</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>14</volume><issue>1</issue><spage>93</spage><epage>97</epage><pages>93-97</pages><issn>1078-8956</issn><eissn>1546-170X</eissn><abstract>Recent successes in treating genetic immunodeficiencies have demonstrated the therapeutic potential of stem cell gene therapy. However, the use of gammaretroviral vectors in these trials led to insertional activation of nearby oncogenes and leukemias in some study subjects, prompting studies of modified or alternative vector systems. Here we describe the use of foamy virus vectors to treat canine leukocyte adhesion deficiency (CLAD). Four of five dogs with CLAD that received nonmyeloablative conditioning and infusion of autologous, CD34+ hematopoietic stem cells transduced by a foamy virus vector expressing canine CD18 had complete reversal of the CLAD phenotype, which was sustained more than 2 years after infusion. In vitro assays showed correction of the lymphocyte proliferation and neutrophil adhesion defects that characterize CLAD. There were no genotoxic complications, and integration site analysis showed polyclonality of transduced cells and a decreased risk of integration near oncogenes as compared to gammaretroviral vectors. These results represent the first successful use of a foamy virus vector to treat a genetic disease, to our knowledge, and suggest that foamy virus vectors will be effective in treating human hematopoietic diseases.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>18157138</pmid><doi>10.1038/nm1695</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1078-8956 |
| ispartof | Nature medicine, 2008-01, Vol.14 (1), p.93-97 |
| issn | 1078-8956 1546-170X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4675671 |
| source | MEDLINE; Nature; Alma/SFX Local Collection |
| subjects | Adhesion Animals Antigens, CD34 - biosynthesis Biomedical and Life Sciences Biomedicine Bone Marrow Cells - metabolism Cancer Research Care and treatment Cell Adhesion Cell Proliferation Dogs Foamy virus Gene mutations Gene therapy Genetic aspects Genetic Therapy - methods Genetic Vectors Genetics Health aspects Hematopoietic Stem Cells - metabolism Immunodeficiency Infectious Diseases letter Leukocyte disorders Leukocyte-Adhesion Deficiency Syndrome - genetics Leukocyte-Adhesion Deficiency Syndrome - therapy Leukocyte-Adhesion Deficiency Syndrome - veterinary Leukocytes Leukocytes - cytology Lymphocytes Lymphocytes - metabolism Medical treatment Metabolic Diseases Molecular Medicine Neurosciences Phenotype Spumavirus - genetics Stem cells Viruses |
| title | Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T15%3A01%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Successful%20treatment%20of%20canine%20leukocyte%20adhesion%20deficiency%20by%20foamy%20virus%20vectors&rft.jtitle=Nature%20medicine&rft.au=Russell,%20David%20W&rft.date=2008-01-01&rft.volume=14&rft.issue=1&rft.spage=93&rft.epage=97&rft.pages=93-97&rft.issn=1078-8956&rft.eissn=1546-170X&rft_id=info:doi/10.1038/nm1695&rft_dat=%3Cgale_pubme%3EA192447741%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=223113647&rft_id=info:pmid/18157138&rft_galeid=A192447741&rfr_iscdi=true |