RAC1 P29S regulates PD-L1 expression in melanoma

Summary Whole exome sequencing of cutaneous melanoma has led to the detection of P29 mutations in RAC1 in 5–9% of samples, but the role of RAC1 P29 mutations in melanoma biology remains unclear. Using reverse phase protein array analysis to examine the changes in protein/phospho‐protein expression,...

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Veröffentlicht in:	Pigment cell and melanoma research 2015-09, Vol.28 (5), p.590-598
Hauptverfasser:	Vu, Ha Linh, Rosenbaum, Sheera, Purwin, Timothy J., Davies, Michael A., Aplin, Andrew E.
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-PD-1 Antibodies Antitumor activity Apoptosis B7-H1 Antigen - metabolism Biomarkers Cell Line, Tumor Collagen - chemistry Cyclin B1 Cyclin B1 - metabolism Exome Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans immune evasion Immune response Immune System Intracellular Signaling Peptides and Proteins - metabolism MAP Kinase Kinase Kinases - metabolism Melanoma Melanoma - immunology Melanoma - metabolism Mutants Mutation Patients PD-1 protein PD-L1 PD-L1 protein Protein arrays Protein-Tyrosine Kinases - metabolism Proteins Proto-Oncogene Protein c-ets-1 - metabolism RAC1 rac1 GTP-Binding Protein - genetics rac1 GTP-Binding Protein - metabolism Rac1 protein RNA Interference Sequence Analysis, DNA Signal Transduction Skin Neoplasms - immunology Skin Neoplasms - metabolism Syk Kinase Syk protein
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