DC Maturation and Function are Not Altered by Melanoma-Derived Immunosuppressive Soluble Factors

Background Although melanoma can elicit robust tumor antigen-specific immune responses, advanced melanoma is associated with immune tolerance. We have previously described several mechanisms of melanoma-induced immunosuppression, including the skewing of the immune response towards a Th2 cytokine pr...

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Veröffentlicht in:	The Journal of surgical research 2012-07, Vol.176 (1), p.301-308
Hauptverfasser:	Baumgartner, Joel M., M.D, Jordan, Kimberly R., Ph.D, Hu, Ling-Jia, Ph.D, Wilson, Cara C., M.D, Banerjee, Anirban, Ph.D, McCarter, Martin D., M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	3-dioxygenase (IDO) Cell Differentiation - drug effects Cell Differentiation - physiology Cell Proliferation - drug effects Cells, Cultured Culture Media, Conditioned - pharmacology Cytokines - metabolism dendritic cells Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - metabolism Endocytosis - drug effects Endocytosis - physiology Humans immunosuppression In Vitro Techniques indoleamine 2 Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism melanoma Melanoma - metabolism Suppressor Factors, Immunologic - metabolism Suppressor Factors, Immunologic - pharmacology Surgery T-Lymphocytes - cytology T-Lymphocytes - drug effects
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