High Pathogenicity of Influenza A (H10N8) Virus in Mice
Three human cases of H10N8 virus infections were initially reported in China in late 2013 and early 2014, two of which were fatal. This was the first time the H10N8 subtype has been detected in humans, and the pathogenicity of this virus remains under characterized. We first assessed its pathogenici...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2015-12, Vol.93 (6), p.1360-1363 |
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| container_title | The American journal of tropical medicine and hygiene |
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| creator | Chen, Haiying Huang, Lihong Li, Hui Zhou, Xianfeng Li, Huanan Sun, Na Qi, Wenbao Xiao, Chencheng Ni, Xiansheng Liu, Mingbin Liao, Ming |
| description | Three human cases of H10N8 virus infections were initially reported in China in late 2013 and early 2014, two of which were fatal. This was the first time the H10N8 subtype has been detected in humans, and the pathogenicity of this virus remains under characterized. We first assessed its pathogenicity by infecting BALB/c mice with two H10N8 isolates, A/Jiangxi-Donghu/346-1/2013 and A/Chicken/Jiangxi/102/2013. The human isolate (H346-1) demonstrated stronger capability of replication and induced higher cytokine response in vivo than the chicken isolate (C102). In addition, H346-1 was fatal to mice, while all mice (N = 14) in C102-infected group survived during the infection course without weight loss. We hypothesized that the 627K mutation in the PB2 gene (PB2-K627) in H346-1 was associated with high pathogenicity in mice. Taken together, this study based on mouse model provides some insight into understanding the pathogenicity of the emerging viruses in mammals. |
| doi_str_mv | 10.4269/ajtmh.15-0064 |
| format | Article |
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This was the first time the H10N8 subtype has been detected in humans, and the pathogenicity of this virus remains under characterized. We first assessed its pathogenicity by infecting BALB/c mice with two H10N8 isolates, A/Jiangxi-Donghu/346-1/2013 and A/Chicken/Jiangxi/102/2013. The human isolate (H346-1) demonstrated stronger capability of replication and induced higher cytokine response in vivo than the chicken isolate (C102). In addition, H346-1 was fatal to mice, while all mice (N = 14) in C102-infected group survived during the infection course without weight loss. We hypothesized that the 627K mutation in the PB2 gene (PB2-K627) in H346-1 was associated with high pathogenicity in mice. Taken together, this study based on mouse model provides some insight into understanding the pathogenicity of the emerging viruses in mammals.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.15-0064</identifier><identifier>PMID: 26350451</identifier><language>eng</language><publisher>United States: The American Society of Tropical Medicine and Hygiene</publisher><subject>Animals ; Cytokines - blood ; Humans ; Influenza A Virus, H10N8 Subtype - pathogenicity ; Influenza, Human - epidemiology ; Influenza, Human - virology ; Lung - pathology ; Lung - virology ; Mice - virology ; Orthomyxoviridae Infections - pathology ; Orthomyxoviridae Infections - virology</subject><ispartof>The American journal of tropical medicine and hygiene, 2015-12, Vol.93 (6), p.1360-1363</ispartof><rights>The American Society of Tropical Medicine and Hygiene.</rights><rights>The American Society of Tropical Medicine and Hygiene 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-220967c26565221409a0f2d86cc939c9da350dcb24fa0ada9fc5e7ad20a7aa593</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674259/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674259/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26350451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Haiying</creatorcontrib><creatorcontrib>Huang, Lihong</creatorcontrib><creatorcontrib>Li, Hui</creatorcontrib><creatorcontrib>Zhou, Xianfeng</creatorcontrib><creatorcontrib>Li, Huanan</creatorcontrib><creatorcontrib>Sun, Na</creatorcontrib><creatorcontrib>Qi, Wenbao</creatorcontrib><creatorcontrib>Xiao, Chencheng</creatorcontrib><creatorcontrib>Ni, Xiansheng</creatorcontrib><creatorcontrib>Liu, Mingbin</creatorcontrib><creatorcontrib>Liao, Ming</creatorcontrib><title>High Pathogenicity of Influenza A (H10N8) Virus in Mice</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>Three human cases of H10N8 virus infections were initially reported in China in late 2013 and early 2014, two of which were fatal. 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Taken together, this study based on mouse model provides some insight into understanding the pathogenicity of the emerging viruses in mammals.</description><subject>Animals</subject><subject>Cytokines - blood</subject><subject>Humans</subject><subject>Influenza A Virus, H10N8 Subtype - pathogenicity</subject><subject>Influenza, Human - epidemiology</subject><subject>Influenza, Human - virology</subject><subject>Lung - pathology</subject><subject>Lung - virology</subject><subject>Mice - virology</subject><subject>Orthomyxoviridae Infections - pathology</subject><subject>Orthomyxoviridae Infections - virology</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkTtPwzAUhS0EoqUwsqKMZQhcO37EC1JVAUUqjwFYrVvHaV2lSYkTpPLr6QMQbEx3OJ-OztVHyCmFC86kvsR5s5hdUBEDSL5HupQrGVPJxT7pAgCLtUxUhxyFMAegKaP0kHSYTARwQbtEjfx0Fj1hM6umrvTWN6uoyqO7Mi9aV35gNIj6IwoP6Xn06us2RL6M7r11x-QgxyK4k6_bIy8318_DUTx-vL0bDsax5QyamDHQUlkmhRSMUQ4aIWdZKq3VibY6w_WQzE4YzxEwQ51b4RRmDFAhCp30yNWud9lOFi6zrmxqLMyy9gusV6ZCb_4mpZ-ZafVuuFScbQv6XwV19da60JiFD9YVBZauaoOhKlVaplyn_0C5lpAqLtdovENtXYVQu_xnEQWz8WK2XgwVZuNlzZ_9fuOH_haRfAKxNYfO</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Chen, Haiying</creator><creator>Huang, Lihong</creator><creator>Li, Hui</creator><creator>Zhou, Xianfeng</creator><creator>Li, Huanan</creator><creator>Sun, Na</creator><creator>Qi, Wenbao</creator><creator>Xiao, Chencheng</creator><creator>Ni, Xiansheng</creator><creator>Liu, Mingbin</creator><creator>Liao, Ming</creator><general>The American Society of Tropical Medicine and Hygiene</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>7U9</scope><scope>C1K</scope><scope>F1W</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope><scope>5PM</scope></search><sort><creationdate>20151201</creationdate><title>High Pathogenicity of Influenza A (H10N8) Virus in Mice</title><author>Chen, Haiying ; 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This was the first time the H10N8 subtype has been detected in humans, and the pathogenicity of this virus remains under characterized. We first assessed its pathogenicity by infecting BALB/c mice with two H10N8 isolates, A/Jiangxi-Donghu/346-1/2013 and A/Chicken/Jiangxi/102/2013. The human isolate (H346-1) demonstrated stronger capability of replication and induced higher cytokine response in vivo than the chicken isolate (C102). In addition, H346-1 was fatal to mice, while all mice (N = 14) in C102-infected group survived during the infection course without weight loss. We hypothesized that the 627K mutation in the PB2 gene (PB2-K627) in H346-1 was associated with high pathogenicity in mice. 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| subjects | Animals Cytokines - blood Humans Influenza A Virus, H10N8 Subtype - pathogenicity Influenza, Human - epidemiology Influenza, Human - virology Lung - pathology Lung - virology Mice - virology Orthomyxoviridae Infections - pathology Orthomyxoviridae Infections - virology |
| title | High Pathogenicity of Influenza A (H10N8) Virus in Mice |
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