Control of developmentally primed erythroid genes by combinatorial co-repressor actions

How transcription factors (TFs) cooperate within large protein complexes to allow rapid modulation of gene expression during development is still largely unknown. Here we show that the key haematopoietic LIM-domain-binding protein-1 (LDB1) TF complex contains several activator and repressor componen...

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Veröffentlicht in:	Nature communications 2015-11, Vol.6 (1), p.8893-8893, Article 8893
Hauptverfasser:	Stadhouders, Ralph, Cico, Alba, Stephen, Tharshana, Thongjuea, Supat, Kolovos, Petros, Baymaz, H. Irem, Yu, Xiao, Demmers, Jeroen, Bezstarosti, Karel, Maas, Alex, Barroca, Vilma, Kockx, Christel, Ozgur, Zeliha, van Ijcken, Wilfred, Arcangeli, Marie-Laure, Andrieu-Soler, Charlotte, Lenhard, Boris, Grosveld, Frank, Soler, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/31 13/89 38/91 631/136/232/1473 631/208/199 631/45/612/822 631/80/86 64/60 82/58 Amino Acid Sequence Animals Base Sequence Carrier Proteins - genetics Carrier Proteins - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epigenetics Erythroid Cells - cytology Erythroid Cells - metabolism Erythropoiesis Gene expression Gene Expression Regulation, Developmental Genomics Humanities and Social Sciences Humans Life Sciences LIM Domain Proteins - genetics LIM Domain Proteins - metabolism Mice Molecular Sequence Data multidisciplinary Nuclear Proteins - genetics Nuclear Proteins - metabolism Nuclear Receptor Co-Repressor 1 - genetics Nuclear Receptor Co-Repressor 1 - metabolism Nuclear Receptor Co-Repressor 2 - genetics Nuclear Receptor Co-Repressor 2 - metabolism Proteins Proteomics Repressor Proteins - genetics Repressor Proteins - metabolism RNA polymerase Science Science (multidisciplinary) Stem cells Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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