An optical biosensor assay for rapid dual detection of Botulinum neurotoxins A and E

The enzymatic activity of the pathogenic botulinum neurotoxins type A and E (BoNT/A and E) leads to potentially lethal paralytic symptoms in humans and their prompt detection is of crucial importance. A chip assay based on Surface Plasmon Resonance monitoring of the cleavage products is a simple met...

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Veröffentlicht in:	Scientific reports 2015-12, Vol.5 (1), p.17953, Article 17953
Hauptverfasser:	Lévêque, Christian, Ferracci, Géraldine, Maulet, Yves, Mazuet, Christelle, Popoff, Michel R., Blanchard, Marie-Pierre, Seagar, Michael, El Far, Oussama
Format:	Artikel
Sprache:	eng
Schlagworte:	13/62 631/1647/277 631/378/548/2589 631/61/168 631/61/32 631/61/350/59 82/1 82/103 9/10 Antibodies, Monoclonal - immunology Biosensing Techniques Biosensors Biotechnology Botulinum Toxins - immunology Botulinum Toxins, Type A - immunology Enzymatic activity Enzyme Activation Epitopes Epitopes - immunology Human health and pathology Humanities and Social Sciences Humans Kinetics Lab-On-A-Chip Devices Life Sciences Microchip Analytical Procedures multidisciplinary Neurons and Cognition Neurotoxins Science Sensitivity and Specificity SNAP-25 protein Substrate Specificity Surface plasmon resonance Toxicology Toxins
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