Dyskerin and TERC expression may condition survival in lung cancer patients

Dyskerin mediates both the modification of uridine on ribosomal and small nuclear RNAs and the stabilization of the telomerase RNA component (TERC). In human tumors dyskerin expression was found to be associated with both rRNA modification and TERC levels. Moreover, dyskerin overexpression has been...

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Veröffentlicht in:	Oncotarget 2015-08, Vol.6 (25), p.21755-21760
Hauptverfasser:	Penzo, Marianna, Ludovini, Vienna, Treré, Davide, Siggillino, Annamaria, Vannucci, Jacopo, Bellezza, Guido, Crinò, Lucio, Montanaro, Lorenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Cell Cycle Proteins - metabolism Clinical Research Paper Female Gene Amplification Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans In Situ Hybridization, Fluorescence Lung Neoplasms - metabolism Lung Neoplasms - mortality Male Middle Aged Neoplasm Recurrence, Local Nuclear Proteins - metabolism RNA - metabolism RNA, Neoplasm - metabolism RNA, Ribosomal - metabolism Telomerase - metabolism Treatment Outcome
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