Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2

TFIIB-related factor 2 (Brf2) is a member of the family of TFIIB-like core transcription factors. Brf2 recruits RNA polymerase (Pol) III to type III gene-external promoters, including the U6 spliceosomal RNA and selenocysteine tRNA genes. Found only in vertebrates, Brf2 has been linked to tumorigene...

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Veröffentlicht in:	Cell 2015-12, Vol.163 (6), p.1375-1387
Hauptverfasser:	Gouge, Jerome, Satia, Karishma, Guthertz, Nicolas, Widya, Marcella, Thompson, Andrew James, Cousin, Pascal, Dergai, Oleksandr, Hernandez, Nouria, Vannini, Alessandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals breast neoplasms carcinogenesis Crystallography, X-Ray DNA - chemistry DNA - metabolism DNA-directed RNA polymerase family Humans lungs mechanistic models Mice Models, Molecular Molecular Sequence Data Oxidation-Reduction oxidative stress RNA RNA Polymerase III - metabolism Saccharomyces cerevisiae selenocysteine Sequence Alignment Signal Transduction spliceosomes transcription (genetics) Transcription Factor TFIIIB - chemistry Transcription Factor TFIIIB - metabolism transcription factors
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