GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP

Brain amyloid deposition is thought to be a seminal event in Alzheimer's disease. To identify genes influencing Alzheimer's disease pathogenesis, we performed a genome-wide association study of longitudinal change in brain amyloid burden measured by (18)F-florbetapir PET. A novel associati...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2015-10, Vol.138 (Pt 10), p.3076-3088
Hauptverfasser:	Ramanan, Vijay K, Risacher, Shannon L, Nho, Kwangsik, Kim, Sungeun, Shen, Li, McDonald, Brenna C, Yoder, Karmen K, Hutchins, Gary D, West, John D, Tallman, Eileen F, Gao, Sujuan, Foroud, Tatiana M, Farlow, Martin R, De Jager, Philip L, Bennett, David A, Aisen, Paul S, Petersen, Ronald C, Jack, Jr, Clifford R, Toga, Arthur W, Green, Robert C, Jagust, William J, Weiner, Michael W, Saykin, Andrew J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - pharmacokinetics Aged Aged, 80 and over Alzheimer Disease - diagnostic imaging Alzheimer Disease - genetics Alzheimer Disease - pathology Amyloid - metabolism Aniline Compounds - metabolism Apolipoprotein E4 - genetics Cerebral Cortex - diagnostic imaging Cerebral Cortex - pathology Ethylene Glycols - metabolism Female Genetic Association Studies Genotype Humans Interleukin-1 Receptor Accessory Protein - genetics Longitudinal Studies Male Original Polymorphism, Single Nucleotide - genetics Positron-Emission Tomography Pyridines - pharmacokinetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!