Effects of Low-Dose Bisphenol A on DNA Damage and Proliferation of Breast Cells: The Role of c-Myc

Humans are exposed to low-dose bisphenol A (BPA) through plastic consumer products and dental sealants containing BPA. Although a number of studies have investigated the mammary gland effects after high-dose BPA exposure, the study findings differ. Furthermore, there has been a lack of mechanistic s...

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Veröffentlicht in:	Environmental health perspectives 2015-12, Vol.123 (12), p.1271-1279
Hauptverfasser:	Pfeifer, Daniella, Chung, Young Min, Hu, Mickey C-T
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Benzhydryl Compounds - toxicity Bioassays Bisphenol A Cancer Cell culture Cell cycle Cell growth Cell Line Cell Line, Tumor Cell Proliferation - drug effects Consumer products Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects Environmental Pollutants - toxicity Estrogen Receptor alpha - metabolism Estrogens Female Gene Silencing Genes Genes, myc Health aspects Humans Kinases Mammary glands Mammary Glands, Human - cytology Mammary Glands, Human - drug effects Mammary Glands, Human - metabolism Phenols - toxicity Phosphorylation Physiological aspects Proteins Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism RNA, Small Interfering - genetics Rodents Up-Regulation Urine
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