Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease

AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2015-12, Vol.21 (45), p.12787-12799
Hauptverfasser:	Lee, Hyun Jung, Yeon, Jong Eun, Ko, Eun Jung, Yoon, Eileen L, Suh, Sang Jun, Kang, Keunhee, Kim, Hae Rim, Kang, Seoung Hee, Yoo, Yang Jae, Je, Jihye, Lee, Beom Jae, Kim, Ji Hoon, Seo, Yeon Seok, Yim, Hyung Joon, Byun, Kwan Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Basic Study Blood Glucose - drug effects Blood Glucose - metabolism Cytoprotection Diet, High-Fat Disease Models, Animal disease Nonalcoholic fatty Gene Expression Regulation Hep G2 Cells Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - pathology Humans Inflammasomes - antagonists & inhibitors Inflammasomes - genetics Inflammasomes - metabolism Inflammation Mediators - metabolism Lipopolysaccharides liver Liver - drug effects Liver - metabolism Liver - pathology Male Mice, Inbred C57BL Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Non-alcoholic Fatty Liver Disease - prevention & control Nonalcoholic Oxidative Stress - drug effects Palmitic Acid - toxicity PPAR delta - agonists PPAR delta - metabolism Signal Transduction - drug effects stea Thiazoles - pharmacology Time Factors
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