Genomic amplification upregulates estrogen-related receptor alpha and its depletion inhibits oral squamous cell carcinoma tumors in vivo

The ESRRA gene encodes a transcription factor and regulates several genes, such as WNT11 and OPN , involved in tumorigenesis. It is upregulated in several cancers, including OSCC. We have previously shown that the tumor suppressor miR-125a targets ESRRA and its downregulation causes upregulation of...

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Veröffentlicht in:	Scientific reports 2015-12, Vol.5 (1), p.17621, Article 17621
Hauptverfasser:	Tiwari, Ankana, Swamy, Shivananda, Gopinath, Kodaganur S., Kumar, Arun
Format:	Artikel
Sprache:	eng
Schlagworte:	38 38/109 38/22 38/89 42 45 45/90 631/67/1536/1665 64 64/60 692/699/67 Apoptosis Apoptosis - genetics Carcinogenesis - genetics Carcinogenesis - pathology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell growth Cell Line, Tumor Cell Proliferation Copy number ERRalpha Estrogen-Related Receptor Estrogens Gene Amplification Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genomics Humanities and Social Sciences Humans Kinases MicroRNAs - genetics MicroRNAs - metabolism Mouth Neoplasms - genetics Mouth Neoplasms - pathology multidisciplinary Neoplasm Invasiveness Oral cancer Oral squamous cell carcinoma Receptors, Estrogen - genetics Receptors, Estrogen - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Science siRNA Squamous cell carcinoma Transcription, Genetic Tumor suppressor genes Tumorigenesis Tumors Up-Regulation - genetics Xenografts
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