The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1

YAP and TAZ are transcriptional co-activators and function as the major effectors of the Hippo tumor suppressor pathway, which controls cell growth, tissue homeostasis, and organ size. Here we show that YAP/TAZ play an essential role in amino acid-induced mTORC1 activation, particularly under nutrie...

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