High Mobility Group B Proteins, Their Partners, and Other Redox Sensors in Ovarian and Prostate Cancer

Cancer cells try to avoid the overproduction of reactive oxygen species by metabolic rearrangements. These cells also develop specific strategies to increase ROS resistance and to express the enzymatic activities necessary for ROS detoxification. Oxidative stress produces DNA damage and also induces...

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Veröffentlicht in:Oxidative medicine and cellular longevity 2016-01, Vol.2016 (2016), p.1-17
Hauptverfasser: Barreiro-Alonso, Aida, Lamas-Maceiras, Monica, Rodriguez-Belmonte, Esther, Vizoso-Vazquez, Angel, Quindos, Maria, Cerdan, M. Esperanza
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container_end_page 17
container_issue 2016
container_start_page 1
container_title Oxidative medicine and cellular longevity
container_volume 2016
creator Barreiro-Alonso, Aida
Lamas-Maceiras, Monica
Rodriguez-Belmonte, Esther
Vizoso-Vazquez, Angel
Quindos, Maria
Cerdan, M. Esperanza
description Cancer cells try to avoid the overproduction of reactive oxygen species by metabolic rearrangements. These cells also develop specific strategies to increase ROS resistance and to express the enzymatic activities necessary for ROS detoxification. Oxidative stress produces DNA damage and also induces responses, which could help the cell to restore the initial equilibrium. But if this is not possible, oxidative stress finally activates signals that will lead to cell death. High mobility group B (HMGB) proteins have been previously related to the onset and progressions of cancers of different origins. The protein HMGB1 behaves as a redox sensor and its structural changes, which are conditioned by the oxidative environment, are associated with different functions of the protein. This review describes recent advances in the role of human HMGB proteins and other proteins interacting with them, in cancerous processes related to oxidative stress, with special reference to ovarian and prostate cancer. Their participation in the molecular mechanisms of resistance to cisplatin, a drug commonly used in chemotherapy, is also revised.
doi_str_mv 10.1155/2016/5845061
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subjects Amino acids
Angiogenesis
Animals
Apoptosis
Autophagy
Biomedical research
Cancer
Chemotherapy
Chromosomal proteins
Deoxyribonucleic acid
Development and progression
DNA
DNA damage
DNA repair
Enzymes
Female
Genes
Genomes
HMGB Proteins - metabolism
Humans
Immune system
Kinases
Localization
Male
Medical research
Neoplasm Proteins - metabolism
Ovarian Neoplasms - metabolism
Ovarian Neoplasms - pathology
Oxidation-Reduction
Oxidative stress
Prostate cancer
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Proteins
Reactive Oxygen Species - metabolism
Review
Sensors
title High Mobility Group B Proteins, Their Partners, and Other Redox Sensors in Ovarian and Prostate Cancer
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