Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody

Neuromyelitis optica (NMO), an autoimmune astrocytopathic disease associated with anti-aquaporin-4 (AQP4) antibody, is characterized by extensive necrotic lesions preferentially involving the optic nerves and spinal cord. However, previous in-vivo experimental models injecting human anti-AQP4 antibo...

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Veröffentlicht in:	Acta neuropathologica communications 2015-12, Vol.3 (1), p.82-82, Article 82
Hauptverfasser:	Kurosawa, Kazuhiro, Misu, Tatsuro, Takai, Yoshiki, Sato, Douglas Kazutoshi, Takahashi, Toshiyuki, Abe, Yoichiro, Iwanari, Hiroko, Ogawa, Ryo, Nakashima, Ichiro, Fujihara, Kazuo, Hamakubo, Takao, Yasui, Masato, Aoki, Masashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Antibody Affinity - drug effects Aquaporin 4 - immunology Aquaporins Astrocytes - metabolism Astrocytes - pathology Calcium-Binding Proteins - metabolism Comparative analysis Complement C9 - metabolism Disease Models, Animal Dose-Response Relationship, Drug Female Humans Immunoglobulin G Immunoglobulin G - adverse effects Intermediate filament proteins Microfilament Proteins - metabolism Monoclonal antibodies Nerve Tissue Proteins - metabolism Neuromyelitis optica Neuromyelitis Optica - chemically induced Neuromyelitis Optica - pathology Neutrophil Infiltration - drug effects Neutrophil Infiltration - physiology Rats Rats, Inbred Lew Time Factors Vacuoles - pathology
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