LY191704: A Selective, Nonsteroidal Inhibitor of Human Steroid 5α- Reductase Type 1

Androgens, in particular dihydrotestosterone (DHT), play a key role in differentiation, growth, and maintenance of the mammalian prostate. Production of DHT from testosterone is catalyzed by two distinct membrane-bound steroid 5α-reductase [5α-reductase; 3-oxo-5α-steroid Δ4-dehydrogenase; 3-oxo-5α-s...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-06, Vol.90 (11), p.5277-5281
Hauptverfasser:	Hirsch, Kenneth S., Jones, Charles D., Audia, James E., Andersson, Stefan, McQuaid, Loretta, Stamm, Nancy B., Neubauer, Blake L., Pennington, Pam, Toomey, Richard E., Russell, David W.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics 5-alpha Reductase Inhibitors Androstenes - pharmacology Animals Azasteroids - pharmacology Biological and medical sciences Cell Line Cell lines Complementary DNA COS cells Cultured cells Enzyme activity Enzymes Finasteride Hormones. Endocrine system Humans Isoenzymes - antagonists & inhibitors Kinetics Male Medical sciences Pharmacology. Drug treatments Prostate Prostate - enzymology Prostatic hyperplasia Quinolones - pharmacology Rats Skin - enzymology Steroids Testosterone Transfection
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