Disruption of 5-HT1A function in adolescence but not early adulthood leads to sustained increases of anxiety
Highlights • Temporary loss of 5-HT1A function after P35, but not after P50, results in increased anxiety-like behaviors in adulthood. • Adolescent blockade of 5-HT1A receptors results in long-term changes in serotonin levels. • Adult anxiety phenotype correlates with increased serotonin levels in s...
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| Veröffentlicht in: | Neuroscience 2016-05, Vol.321, p.210-221 |
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| container_title | Neuroscience |
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| creator | Garcia-Garcia, A.L Meng, Q Richardson-Jones, J Dranovsky, A Leonardo, E.D |
| description | Highlights • Temporary loss of 5-HT1A function after P35, but not after P50, results in increased anxiety-like behaviors in adulthood. • Adolescent blockade of 5-HT1A receptors results in long-term changes in serotonin levels. • Adult anxiety phenotype correlates with increased serotonin levels in select brain regions. • Brief interventions in the 5-HT system during adolescence lead to profound and enduring changes in behavior. |
| doi_str_mv | 10.1016/j.neuroscience.2015.05.076 |
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Meng, Q ; Richardson-Jones, J ; Dranovsky, A ; Leonardo, E.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e415t-464745746ef7fea8935cef0b0351019dfb677da023704083ee859cc232fdb1373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>5-HT1A</topic><topic>8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology</topic><topic>adolescence</topic><topic>Age Factors</topic><topic>Animals</topic><topic>anxiety</topic><topic>Anxiety - metabolism</topic><topic>Anxiety - psychology</topic><topic>Conflict (Psychology)</topic><topic>Corticosterone - blood</topic><topic>depression</topic><topic>development</topic><topic>Male</topic><topic>Mice, Knockout</topic><topic>Neurology</topic><topic>Piperazines - pharmacology</topic><topic>Pyridines - pharmacology</topic><topic>Receptor, Serotonin, 5-HT1A - genetics</topic><topic>Receptor, Serotonin, 5-HT1A - physiology</topic><topic>serotonin</topic><topic>Serotonin - physiology</topic><topic>Serotonin 5-HT1 Receptor Agonists - pharmacology</topic><topic>Serotonin 5-HT1 Receptor Antagonists - pharmacology</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia-Garcia, A.L</creatorcontrib><creatorcontrib>Meng, Q</creatorcontrib><creatorcontrib>Richardson-Jones, J</creatorcontrib><creatorcontrib>Dranovsky, A</creatorcontrib><creatorcontrib>Leonardo, E.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia-Garcia, A.L</au><au>Meng, Q</au><au>Richardson-Jones, J</au><au>Dranovsky, A</au><au>Leonardo, E.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disruption of 5-HT1A function in adolescence but not early adulthood leads to sustained increases of anxiety</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2016-05-03</date><risdate>2016</risdate><volume>321</volume><spage>210</spage><epage>221</epage><pages>210-221</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><abstract>Highlights • Temporary loss of 5-HT1A function after P35, but not after P50, results in increased anxiety-like behaviors in adulthood. • Adolescent blockade of 5-HT1A receptors results in long-term changes in serotonin levels. • Adult anxiety phenotype correlates with increased serotonin levels in select brain regions. • Brief interventions in the 5-HT system during adolescence lead to profound and enduring changes in behavior.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>26049143</pmid><doi>10.1016/j.neuroscience.2015.05.076</doi><tpages>12</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 5-HT1A 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology adolescence Age Factors Animals anxiety Anxiety - metabolism Anxiety - psychology Conflict (Psychology) Corticosterone - blood depression development Male Mice, Knockout Neurology Piperazines - pharmacology Pyridines - pharmacology Receptor, Serotonin, 5-HT1A - genetics Receptor, Serotonin, 5-HT1A - physiology serotonin Serotonin - physiology Serotonin 5-HT1 Receptor Agonists - pharmacology Serotonin 5-HT1 Receptor Antagonists - pharmacology Signal Transduction |
| title | Disruption of 5-HT1A function in adolescence but not early adulthood leads to sustained increases of anxiety |
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