Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion

The mammalian transcription factors CLOCK and BMAL1 are essential components of the molecular clock that coordinate behavior and metabolism with the solar cycle. Genetic or environmental perturbation of circadian cycles contributes to metabolic disorders including type 2 diabetes. To study the impac...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2015-11, Vol.350 (6261), p.650-650
Hauptverfasser:	Perelis, Mark, Marcheva, Biliana, Ramsey, Kathryn Moynihan, Schipma, Matthew J., Hutchison, Alan L., Taguchi, Akihiko, Peek, Clara Bien, Hong, Heekyung, Huang, Wenyu, Omura, Chiaki, Allred, Amanda L., Bradfield, Christopher A., Dinner, Aaron R., Barish, Grant D., Bass, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ARNTL Transcription Factors - genetics ARNTL Transcription Factors - metabolism Circadian Rhythm - genetics CLOCK Proteins - metabolism Clocks Diabetes Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Enhancer Elements, Genetic - physiology Exocytosis - genetics Gene expression Gene Expression Regulation Genes Glucose Glucose Intolerance Homeodomain Proteins - metabolism Humans Insulin Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - metabolism Liver - metabolism Male Mice Mice, Inbred C57BL RESEARCH ARTICLE SUMMARY Secretions Trans-Activators - metabolism Transcription, Genetic
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