Neural Activity in Human Hippocampal Formation Reveals the Spatial Context of Retrieved Memories
In many species, spatial navigation is supported by a network of place cells that exhibit increased firing whenever an animal is in a certain region of an environment. Does this neural representation of location form part of the spatiotemporal context into which episodic memories are encoded? We rec...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2013-11, Vol.342 (6162), p.1111-1114 |
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| creator | Miller, Jonathan F. Neufang, Markus Solway, Alec Brandt, Armin Trippel, Michael Mader, Irina Hefft, Stefan Merkow, Max Polyn, Sean M. Jacobs, Joshua Kahana, Michael J. Schulze-Bonhage, Andreas |
| description | In many species, spatial navigation is supported by a network of place cells that exhibit increased firing whenever an animal is in a certain region of an environment. Does this neural representation of location form part of the spatiotemporal context into which episodic memories are encoded? We recorded medial temporal lobe neuronal activity as epilepsy patients performed a hybrid spatial and episodic memory task. We identified place-responsive cells active during virtual navigation and then asked whether the same cells activated during the subsequent recall of navigation-related memories without actual navigation. Place-responsive cell activity was reinstated during episodic memory retrieval. Neuronal firing during the retrieval of each memory was similar to the activity that represented the locations in the environment where the memory was initially encoded. |
| doi_str_mv | 10.1126/science.1244056 |
| format | Article |
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Does this neural representation of location form part of the spatiotemporal context into which episodic memories are encoded? We recorded medial temporal lobe neuronal activity as epilepsy patients performed a hybrid spatial and episodic memory task. We identified place-responsive cells active during virtual navigation and then asked whether the same cells activated during the subsequent recall of navigation-related memories without actual navigation. Place-responsive cell activity was reinstated during episodic memory retrieval. Neuronal firing during the retrieval of each memory was similar to the activity that represented the locations in the environment where the memory was initially encoded.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1244056</identifier><identifier>PMID: 24288336</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Biological and medical sciences ; Cell Separation ; cognition ; Cognition & reasoning ; Cognitive Mapping ; Computer Simulation ; Educational Games ; Electrodes, Implanted ; Environment ; Epilepsy ; Fundamental and applied biological sciences. Psychology ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; hippocampus ; Hippocampus - cytology ; Hippocampus - physiology ; Humans ; Medical sciences ; Memory ; Memory, Episodic ; Navigation ; Nervous system (semeiology, syndromes) ; Neurobiology ; Neurology ; neurons ; Neurons - physiology ; Neurotransmitters ; patients ; Recall (Psychology) ; space and time ; Space Perception - physiology ; Studies ; Temporal Lobe - cytology ; Temporal Lobe - physiology ; User-Computer Interface ; Vertebrates: nervous system and sense organs</subject><ispartof>Science (American Association for the Advancement of Science), 2013-11, Vol.342 (6162), p.1111-1114</ispartof><rights>Copyright © 2013 American Association for the Advancement of Science</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c605t-439c22488a213c98e1c4271a4ce5981b04438aa2b1991340e7eceb0dc7f06ed33</citedby><cites>FETCH-LOGICAL-c605t-439c22488a213c98e1c4271a4ce5981b04438aa2b1991340e7eceb0dc7f06ed33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/42913784$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/42913784$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,2870,2871,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28073685$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24288336$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller, Jonathan F.</creatorcontrib><creatorcontrib>Neufang, Markus</creatorcontrib><creatorcontrib>Solway, Alec</creatorcontrib><creatorcontrib>Brandt, Armin</creatorcontrib><creatorcontrib>Trippel, Michael</creatorcontrib><creatorcontrib>Mader, Irina</creatorcontrib><creatorcontrib>Hefft, Stefan</creatorcontrib><creatorcontrib>Merkow, Max</creatorcontrib><creatorcontrib>Polyn, Sean M.</creatorcontrib><creatorcontrib>Jacobs, Joshua</creatorcontrib><creatorcontrib>Kahana, Michael J.</creatorcontrib><creatorcontrib>Schulze-Bonhage, Andreas</creatorcontrib><title>Neural Activity in Human Hippocampal Formation Reveals the Spatial Context of Retrieved Memories</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>In many species, spatial navigation is supported by a network of place cells that exhibit increased firing whenever an animal is in a certain region of an environment. Does this neural representation of location form part of the spatiotemporal context into which episodic memories are encoded? We recorded medial temporal lobe neuronal activity as epilepsy patients performed a hybrid spatial and episodic memory task. We identified place-responsive cells active during virtual navigation and then asked whether the same cells activated during the subsequent recall of navigation-related memories without actual navigation. Place-responsive cell activity was reinstated during episodic memory retrieval. Neuronal firing during the retrieval of each memory was similar to the activity that represented the locations in the environment where the memory was initially encoded.</description><subject>Biological and medical sciences</subject><subject>Cell Separation</subject><subject>cognition</subject><subject>Cognition & reasoning</subject><subject>Cognitive Mapping</subject><subject>Computer Simulation</subject><subject>Educational Games</subject><subject>Electrodes, Implanted</subject><subject>Environment</subject><subject>Epilepsy</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>hippocampus</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - physiology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>Memory, Episodic</subject><subject>Navigation</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>neurons</subject><subject>Neurons - physiology</subject><subject>Neurotransmitters</subject><subject>patients</subject><subject>Recall (Psychology)</subject><subject>space and time</subject><subject>Space Perception - physiology</subject><subject>Studies</subject><subject>Temporal Lobe - cytology</subject><subject>Temporal Lobe - physiology</subject><subject>User-Computer Interface</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkstv1DAQxi0EotuFMydQJFSJS9rxI45zQapWlCIVkHicjdc7oV4lcWo7K_rf47JheVx6sa35fjPSfP4IeUbhlFImz6J1OFg8pUwIqOQDsqDQVGXDgD8kCwAuSwV1dUSOY9wCZK3hj8kRE0wpzuWCfPuAUzBdcW6T27l0W7ihuJx6k083jt6afszqhQ-9Sc4PxSfcoelika6x-DzmWlZXfkj4IxW-zXIKLiOb4j32Pj_jE_KozQ34dL6X5OvFmy-ry_Lq49t3q_Or0kqoUil4YxkTShlGuW0UUitYTY2wWDWKrkEIroxha9o0lAvAGi2uYWPrFiRuOF-S1_u547TucWNxSHkvPQbXm3CrvXH6X2Vw1_q732khZUOB5QGv5gHB30wYk-5dtNh1ZkA_Rc2yfVwBiPtRKlUtlWSc3o8KyWrJoVIZffkfuvVTGLJpvyjF6jsTluRsT9ngYwzYHlakoO8yoedM6DkTuePF384c-N8hyMDJDJhoTdcGM1gX_3A5QVyqKnPP99w2Jh8OumD5R2ol-E8NCsl8</recordid><startdate>20131129</startdate><enddate>20131129</enddate><creator>Miller, Jonathan F.</creator><creator>Neufang, Markus</creator><creator>Solway, Alec</creator><creator>Brandt, Armin</creator><creator>Trippel, Michael</creator><creator>Mader, Irina</creator><creator>Hefft, Stefan</creator><creator>Merkow, Max</creator><creator>Polyn, Sean M.</creator><creator>Jacobs, Joshua</creator><creator>Kahana, Michael J.</creator><creator>Schulze-Bonhage, Andreas</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20131129</creationdate><title>Neural Activity in Human Hippocampal Formation Reveals the Spatial Context of Retrieved Memories</title><author>Miller, Jonathan F. ; Neufang, Markus ; Solway, Alec ; Brandt, Armin ; Trippel, Michael ; Mader, Irina ; Hefft, Stefan ; Merkow, Max ; Polyn, Sean M. ; Jacobs, Joshua ; Kahana, Michael J. ; Schulze-Bonhage, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c605t-439c22488a213c98e1c4271a4ce5981b04438aa2b1991340e7eceb0dc7f06ed33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Biological and medical sciences</topic><topic>Cell Separation</topic><topic>cognition</topic><topic>Cognition & reasoning</topic><topic>Cognitive Mapping</topic><topic>Computer Simulation</topic><topic>Educational Games</topic><topic>Electrodes, Implanted</topic><topic>Environment</topic><topic>Epilepsy</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>hippocampus</topic><topic>Hippocampus - cytology</topic><topic>Hippocampus - physiology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Memory</topic><topic>Memory, Episodic</topic><topic>Navigation</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>neurons</topic><topic>Neurons - physiology</topic><topic>Neurotransmitters</topic><topic>patients</topic><topic>Recall (Psychology)</topic><topic>space and time</topic><topic>Space Perception - physiology</topic><topic>Studies</topic><topic>Temporal Lobe - cytology</topic><topic>Temporal Lobe - physiology</topic><topic>User-Computer Interface</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller, Jonathan F.</creatorcontrib><creatorcontrib>Neufang, Markus</creatorcontrib><creatorcontrib>Solway, Alec</creatorcontrib><creatorcontrib>Brandt, Armin</creatorcontrib><creatorcontrib>Trippel, Michael</creatorcontrib><creatorcontrib>Mader, Irina</creatorcontrib><creatorcontrib>Hefft, Stefan</creatorcontrib><creatorcontrib>Merkow, Max</creatorcontrib><creatorcontrib>Polyn, Sean M.</creatorcontrib><creatorcontrib>Jacobs, Joshua</creatorcontrib><creatorcontrib>Kahana, Michael J.</creatorcontrib><creatorcontrib>Schulze-Bonhage, Andreas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miller, Jonathan F.</au><au>Neufang, Markus</au><au>Solway, Alec</au><au>Brandt, Armin</au><au>Trippel, Michael</au><au>Mader, Irina</au><au>Hefft, Stefan</au><au>Merkow, Max</au><au>Polyn, Sean M.</au><au>Jacobs, Joshua</au><au>Kahana, Michael J.</au><au>Schulze-Bonhage, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neural Activity in Human Hippocampal Formation Reveals the Spatial Context of Retrieved Memories</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2013-11-29</date><risdate>2013</risdate><volume>342</volume><issue>6162</issue><spage>1111</spage><epage>1114</epage><pages>1111-1114</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>In many species, spatial navigation is supported by a network of place cells that exhibit increased firing whenever an animal is in a certain region of an environment. Does this neural representation of location form part of the spatiotemporal context into which episodic memories are encoded? We recorded medial temporal lobe neuronal activity as epilepsy patients performed a hybrid spatial and episodic memory task. We identified place-responsive cells active during virtual navigation and then asked whether the same cells activated during the subsequent recall of navigation-related memories without actual navigation. Place-responsive cell activity was reinstated during episodic memory retrieval. Neuronal firing during the retrieval of each memory was similar to the activity that represented the locations in the environment where the memory was initially encoded.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>24288336</pmid><doi>10.1126/science.1244056</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Science (American Association for the Advancement of Science), 2013-11, Vol.342 (6162), p.1111-1114 |
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| subjects | Biological and medical sciences Cell Separation cognition Cognition & reasoning Cognitive Mapping Computer Simulation Educational Games Electrodes, Implanted Environment Epilepsy Fundamental and applied biological sciences. Psychology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy hippocampus Hippocampus - cytology Hippocampus - physiology Humans Medical sciences Memory Memory, Episodic Navigation Nervous system (semeiology, syndromes) Neurobiology Neurology neurons Neurons - physiology Neurotransmitters patients Recall (Psychology) space and time Space Perception - physiology Studies Temporal Lobe - cytology Temporal Lobe - physiology User-Computer Interface Vertebrates: nervous system and sense organs |
| title | Neural Activity in Human Hippocampal Formation Reveals the Spatial Context of Retrieved Memories |
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