Polymeric oncolytic adenovirus for cancer gene therapy
Oncolytic adenovirus (Ad) vectors present a promising modality to treat cancer. Many clinical trials have been done with either naked oncolytic Ad or combination with chemotherapies. However, the systemic injection of oncolytic Ad in clinical applications is restricted due to significant liver toxic...
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| Veröffentlicht in: | Journal of controlled release 2015-12, Vol.219, p.181-191 |
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| creator | Choi, Joung-Woo Lee, Young Sook Yun, Chae-Ok Kim, Sung Wan |
| description | Oncolytic adenovirus (Ad) vectors present a promising modality to treat cancer. Many clinical trials have been done with either naked oncolytic Ad or combination with chemotherapies. However, the systemic injection of oncolytic Ad in clinical applications is restricted due to significant liver toxicity and immunogenicity. To overcome these issues, Ad has been engineered physically or chemically with numerous polymers for shielding the Ad surface, accomplishing extended blood circulation time and reduced immunogenicity as well as hepatotoxicity. In this review, we describe and classify the characteristics of polymer modified oncolytic Ad following each strategy for cancer treatment. Furthermore, this review concludes with the highlights of various polymer-coated Ads and their prospects, and directions for future research.
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| doi_str_mv | 10.1016/j.jconrel.2015.10.009 |
| format | Article |
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[Display omitted]</description><subject>Active targeting</subject><subject>Adenoviridae</subject><subject>Adenoviridae - chemistry</subject><subject>Animals</subject><subject>blood circulation</subject><subject>Cancer gene therapy</subject><subject>Clinical trials</subject><subject>gene therapy</subject><subject>Genetic Therapy</subject><subject>Genetic Vectors</subject><subject>hepatotoxicity</subject><subject>Humans</subject><subject>immune response</subject><subject>neoplasms</subject><subject>Neoplasms - therapy</subject><subject>Oncolytic Ad/polymer hybrid vector</subject><subject>Oncolytic adenovirus</subject><subject>Oncolytic Virotherapy - methods</subject><subject>Oncolytic Viruses - chemistry</subject><subject>polymers</subject><subject>Polymers - chemistry</subject><subject>Static Electricity</subject><subject>Systemic administration</subject><subject>Tumor Microenvironment</subject><subject>Tumor microenvironment targeting</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EoqXwCaAs2aTY8SPxBoQqXlIlWMDacpxJ6yqJi51U6t_jqgXBitWMZu7cOzoIXRI8JZiIm9V0ZVznoZlmmPA4m2Isj9CYFDlNmZT8GI2jrkip4HKEzkJYYYw5ZfkpGmWCcVpgMUbizTXbFrw1ietM7PvY6Qo6t7F-CEntfGJ0Z8AnC-gg6Zfg9Xp7jk5q3QS4ONQJ-nh8eJ89p_PXp5fZ_Tw1AtM-pYRKZrKMc4CalhpEibOSypqyzFSy0oJJCkaUeVGRnIvaRKUkGkOdaV5xOkG3e9_1ULZQGeh6rxu19rbVfqucturvprNLtXAbxYQoJGXR4Ppg4N3nAKFXrQ0GmkZ34IagsgiFEYLlLovvpca7EDzUPzEEqx1ztVIH5mrHfDeOzOPd1e8ff66-IUfB3V4AkdTGglfBWIhMK-vB9Kpy9p-IL_vVlvc</recordid><startdate>20151210</startdate><enddate>20151210</enddate><creator>Choi, Joung-Woo</creator><creator>Lee, Young Sook</creator><creator>Yun, Chae-Ok</creator><creator>Kim, Sung Wan</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20151210</creationdate><title>Polymeric oncolytic adenovirus for cancer gene therapy</title><author>Choi, Joung-Woo ; Lee, Young Sook ; Yun, Chae-Ok ; Kim, Sung Wan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c603t-31394c2255eef3bae6b02b39f342cd9da6493ec6b78d1756fc55e91a0ef2a5d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Active targeting</topic><topic>Adenoviridae</topic><topic>Adenoviridae - chemistry</topic><topic>Animals</topic><topic>blood circulation</topic><topic>Cancer gene therapy</topic><topic>Clinical trials</topic><topic>gene therapy</topic><topic>Genetic Therapy</topic><topic>Genetic Vectors</topic><topic>hepatotoxicity</topic><topic>Humans</topic><topic>immune response</topic><topic>neoplasms</topic><topic>Neoplasms - therapy</topic><topic>Oncolytic Ad/polymer hybrid vector</topic><topic>Oncolytic adenovirus</topic><topic>Oncolytic Virotherapy - methods</topic><topic>Oncolytic Viruses - chemistry</topic><topic>polymers</topic><topic>Polymers - chemistry</topic><topic>Static Electricity</topic><topic>Systemic administration</topic><topic>Tumor Microenvironment</topic><topic>Tumor microenvironment targeting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Joung-Woo</creatorcontrib><creatorcontrib>Lee, Young Sook</creatorcontrib><creatorcontrib>Yun, Chae-Ok</creatorcontrib><creatorcontrib>Kim, Sung Wan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Joung-Woo</au><au>Lee, Young Sook</au><au>Yun, Chae-Ok</au><au>Kim, Sung Wan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymeric oncolytic adenovirus for cancer gene therapy</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2015-12-10</date><risdate>2015</risdate><volume>219</volume><spage>181</spage><epage>191</epage><pages>181-191</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><abstract>Oncolytic adenovirus (Ad) vectors present a promising modality to treat cancer. 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| ispartof | Journal of controlled release, 2015-12, Vol.219, p.181-191 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Active targeting Adenoviridae Adenoviridae - chemistry Animals blood circulation Cancer gene therapy Clinical trials gene therapy Genetic Therapy Genetic Vectors hepatotoxicity Humans immune response neoplasms Neoplasms - therapy Oncolytic Ad/polymer hybrid vector Oncolytic adenovirus Oncolytic Virotherapy - methods Oncolytic Viruses - chemistry polymers Polymers - chemistry Static Electricity Systemic administration Tumor Microenvironment Tumor microenvironment targeting |
| title | Polymeric oncolytic adenovirus for cancer gene therapy |
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