MicroRNA-195 inhibits proliferation, invasion and metastasis in breast cancer cells by targeting FASN, HMGCR, ACACA and CYP27B1

De novo lipogenesis, a hallmark for cancers is required for cellular transformation. Further it is believed that resistance to apoptosis and epithelial-to-mesenchymal-transition(EMT) facilitates metastasis via over-expression of anti-apoptotic Bcl-2. Previously we demonstrated that hsa-miR-195 targe...

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Veröffentlicht in:	Scientific reports 2015-12, Vol.5 (1), p.17454-17454, Article 17454
Hauptverfasser:	Singh, Richa, Yadav, Vikas, kumar, Sachin, Saini, Neeru
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - metabolism 38 38/39 38/61 38/77 631/154/51/2310 631/45 631/67 631/80 96 96/106 96/2 96/31 96/63 Acetyl-CoA Carboxylase - genetics Acetyl-CoA Carboxylase - metabolism Apoptosis Bcl protein Bcl-2 protein Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Movement - genetics Cell Proliferation Cholesterol Ectopic expression Enzymes Epithelial-Mesenchymal Transition - genetics Etoposide Fatty Acid Synthase, Type I - genetics Fatty Acid Synthase, Type I - metabolism Fatty acids Female Gene expression Gene Expression Regulation, Neoplastic Genetic transformation Humanities and Social Sciences Humans Hydroxymethylglutaryl CoA Reductases - genetics Hydroxymethylglutaryl CoA Reductases - metabolism Lipid Metabolism - genetics Lipogenesis Mesenchyme Metabolism Metastases Metastasis MicroRNAs - genetics MicroRNAs - metabolism miRNA Mitochondria Mitochondria - genetics Mitochondria - metabolism multidisciplinary Overexpression Science
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