Effects of Etanercept against Transient Cerebral Ischemia in Diabetic Rats

Diabetes mellitus is known to exacerbate acute cerebral ischemic injury. Previous studies have demonstrated that infarction volumes caused by transient cerebral ischemia were greater in diabetic rats than in nondiabetic rats. Tumor necrosis factor-α (TNF-α) is a proinflammatory protein produced in t...

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Veröffentlicht in:	BioMed research international 2015-01, Vol.2015 (2015), p.1-10
Hauptverfasser:	Hibino, Yasuhide, Okazaki, Mari, Matsuzaki, Hirokazu, Xuan, Meiyan, Takayama, Hiroko, Iwata, Naohiro, Kamiuchi, Shinya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Biological activity Biomedical research Brain damage Cerebral ischemia Cytokines Diabetes Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - physiopathology Dosage and administration Drug therapy Etanercept Etanercept - administration & dosage Humans Infarction, Middle Cerebral Artery - drug therapy Infarction, Middle Cerebral Artery - genetics Infarction, Middle Cerebral Artery - physiopathology Inflammation Inflammation - drug therapy Inflammation - genetics Inflammation - pathology Ischemia Ischemic Attack, Transient - complications Ischemic Attack, Transient - drug therapy Ischemic Attack, Transient - genetics Ischemic Attack, Transient - physiopathology Laboratories Mortality Neuroprotective Agents Oxidative stress Pathogenesis Patient outcomes Pharmaceutical sciences Pharmaceuticals Physiological aspects Rats Rodents Studies Traumatic brain injury Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF
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