New insight into long-range nonadditivity within protein double-mutant cycles

Additivity principles in chemistry, biochemistry, and biophysics have been used extensively for decades. Nevertheless, it is well known that additivity frequently breaks down in complex biomacromolecules. Nonadditivity within protein double mutant free energy cycles of spatially close residue pairs...

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Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2008-02, Vol.70 (3), p.915-924
Hauptverfasser:	Istomin, Andrei Y., Gromiha, M. Michael, Vorov, Oleg K., Jacobs, Donald J., Livesay, Dennis R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms cooperativity double mutant cycle free energy nonadditivity Kinetics Mutation network rigidity Protein Conformation Protein Folding protein structure Proteins - chemistry Proteins - genetics Thermodynamics
Online-Zugang:	Volltext
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