Commensal–dendritic-cell interaction specifies a unique protective skin immune signature

Defined skin commensal bacteria elicit a dermal dendritic-cell-dependent, long-lasting, commensal-specific CD8 + T-cell response that promotes protection against pathogens while preserving tissue homeostasis. Interactions between skin bacteria and the immune system The importance of our gut microbio...

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Veröffentlicht in:	Nature (London) 2015-04, Vol.520 (7545), p.104-108
Hauptverfasser:	Naik, Shruti, Bouladoux, Nicolas, Linehan, Jonathan L., Han, Seong-Ji, Harrison, Oliver J., Wilhelm, Christoph, Conlan, Sean, Himmelfarb, Sarah, Byrd, Allyson L., Deming, Clayton, Quinones, Mariam, Brenchley, Jason M., Kong, Heidi H., Tussiwand, Roxanne, Murphy, Kenneth M., Merad, Miriam, Segre, Julia A., Belkaid, Yasmine
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/31 14/19 38/22 38/23 38/39 45/90 631/250 64/60 Animals Antigens Antigens, Bacterial - immunology Biofilms CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Cell interaction Cytokines Dendritic cells Dendritic Cells - cytology Dendritic Cells - immunology Epidermis Gene expression Health aspects Humanities and Social Sciences Humans Identification and classification Immune response Immune system Immunity, Innate - immunology Interleukin-17 - immunology Langerhans Cells - cytology Langerhans Cells - immunology letter Lymphocytes Mice Mice, Inbred BALB C Mice, Inbred C57BL Microbial activity Microorganisms multidisciplinary Pathogens Physiological aspects Primates Science Skin Skin - cytology Skin - immunology Skin - microbiology Staphylococcus epidermidis - immunology Symbiosis - immunology T cell receptors
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