RANKL–RANK signaling regulates expression of xenotropic and polytropic virus receptor (XPR1) in osteoclasts

► XPR1 is a receptor for xenotropic and polytropic viruses. ► XPR1 is expressed in monocyte precursors of osteoclasts. ► RANKL–RANK signaling differentiates osteoclast precursors into osteoclasts. ► RANKL–RANK signaling up-regulates XPR1 mRNA in differentiated osteoclasts. ► XPR1 protein is localize...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-08, Vol.399 (2), p.129-132
Hauptverfasser:	Sharma, Parul, Patntirapong, Somying, Hann, Steven, Hauschka, Peter V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone marrow Cell Line GEDI Mice Mice, Inbred C57BL Mice, Transgenic Microarray Murine leukemia virus Osteoclastogenesis Osteoclasts - metabolism RANK Ligand - metabolism Receptor Activator of Nuclear Factor-kappa B - metabolism Receptors, G-Protein-Coupled - biosynthesis Receptors, G-Protein-Coupled - genetics Receptors, Virus - biosynthesis Receptors, Virus - genetics Signal Transduction Virus receptor XPR1
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