Engineering and expression of a human rotavirus candidate vaccine in Nicotiana benthamiana

Human rotaviruses are the main cause of severe gastroenteritis in children and are responsible for over 500 000 deaths annually. There are two live rotavirus vaccines currently available, one based on human rotavirus serotype G1P[8], and the other a G1-G4 P[8] pentavalent vaccine. However, the recen...

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Veröffentlicht in:	Virology journal 2015-12, Vol.12 (1), p.205-205, Article 205
Hauptverfasser:	Pêra, Francisco F P G, Mutepfa, David L R, Khan, Ayesha M, Els, Johann H, Mbewana, Sandiswa, van Dijk, Alberdina A A, Rybicki, Edward P, Hitzeroth, Inga I
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antigens Antigens, Viral - genetics Antigens, Viral - immunology Capsid Proteins - genetics Capsid Proteins - immunology Developing countries Development and progression Gastroenteritis Gastroenteritis - prevention & control Gastroenteritis - virology Genotype Humans Microscopy, Electron, Transmission Molecular Sequence Data Nicotiana - genetics Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Rotavirus - classification Rotavirus - genetics Rotavirus - immunology Rotavirus Infections - prevention & control Rotavirus Infections - virology Rotavirus Vaccines - genetics Rotavirus Vaccines - immunology Rotavirus Vaccines - isolation & purification Sequence Analysis, DNA Vaccines Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vaccines, Synthetic - isolation & purification Vaccines, Virus-Like Particle - genetics Vaccines, Virus-Like Particle - immunology Vaccines, Virus-Like Particle - isolation & purification Viral proteins
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