Serum bilirubin concentration is modified by UGT1A1 haplotypes and influences risk of type-2 diabetes in the Norfolk Island genetic isolate

Located in the Pacific Ocean between Australia and New Zealand, the unique population isolate of Norfolk Island has been shown to exhibit increased prevalence of metabolic disorders (type-2 diabetes, cardiovascular disease) compared to mainland Australia. We investigated this well-established geneti...

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Veröffentlicht in:	BMC genetics 2015-12, Vol.16 (1), p.136-136, Article 136
Hauptverfasser:	Benton, M C, Lea, R A, Macartney-Coxson, D, Bellis, C, Carless, M A, Curran, J E, Hanna, M, Eccles, D, Chambers, G K, Blangero, J, Griffiths, L R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Base Sequence Bilirubin - blood Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - complications Cardiovascular Diseases - genetics Chromosomes Chromosomes, Human, Pair 2 - genetics Comparative analysis Development and progression Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - enzymology Diabetes Mellitus, Type 2 - genetics Enzymes Epidemiology Genes, Recessive Genetic aspects Genetic markers Genetic Predisposition to Disease Genetic research Genome-Wide Association Study Genomes Genomics Glucuronosyltransferase - genetics Haplotypes - genetics Humans Inheritance Patterns - genetics Linkage Disequilibrium Medical research Medicine, Experimental Melanesia Metabolic Syndrome - complications Metabolic Syndrome - genetics Metabolism Molecular Sequence Annotation Molecular Sequence Data Polymorphism, Single Nucleotide - genetics Risk Factors Type 2 diabetes
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