Design and Evaluation of the Highly Concentrated Human IgG Formulation Using Cyclodextrin Polypseudorotaxane Hydrogels

To achieve the potent therapeutic effects of human immunoglobulin G (IgG), highly concentrated formulations are required. However, the stabilization for highly concentrated human IgG is laborious work. In the present study, to investigate the potentials of polypseudorotaxane (PPRX) hydrogels consist...

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Veröffentlicht in:	AAPS PharmSciTech 2015-12, Vol.16 (6), p.1290-1298
Hauptverfasser:	Higashi, Taishi, Tajima, Anna, Ohshita, Naoko, Hirotsu, Tatsunori, Hashim, Irhan Ibrahim Abu, Motoyama, Keiichi, Koyama, Sawako, Iibuchi, Ruriko, Mieda, Shiuhei, Handa, Kenji, Kimoto, Tomoaki, Arima, Hidetoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Chemistry, Pharmaceutical - methods Cyclodextrins - chemistry Delayed-Action Preparations - chemistry Drug Carriers - chemistry Drug Delivery Systems - methods gamma-Cyclodextrins - chemistry Humans Hydrogels - chemistry Immunoglobulin G - chemistry Pharmacology/Toxicology Pharmacy Polyethylene Glycols - chemistry Research Article Rotaxanes - chemistry X-Ray Diffraction - methods
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