iTRAQ proteomic analysis of extracellular matrix remodeling in aortic valve disease

Degenerative aortic stenosis (AS) is the most common worldwide cause of valve replacement. The aortic valve is a thin, complex, layered connective tissue with compartmentalized extracellular matrix (ECM) produced by specialized cell types, which directs blood flow in one direction through the heart....

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Veröffentlicht in:	Scientific reports 2015-12, Vol.5 (1), p.17290-17290, Article 17290
Hauptverfasser:	Martin-Rojas, Tatiana, Mourino-Alvarez, Laura, Alonso-Orgaz, Sergio, Rosello-Lleti, Esther, Calvo, Enrique, Lopez-Almodovar, Luis Fernando, Rivera, Miguel, Padial, Luis R., Lopez, Juan Antonio, Cuesta, Fernando de la, Barderas, Maria G.
Format:	Artikel
Sprache:	eng
Schlagworte:	101/1 631/337/475 692/53 692/699/75/591 82/16 82/58 Aged Aortic stenosis Aortic valve Aortic Valve Stenosis - metabolism Aortic Valve Stenosis - pathology Blood flow Electrocardiography Extracellular matrix Extracellular Matrix - metabolism Extracellular Matrix - pathology Extracellular Matrix Proteins - metabolism Female Humanities and Social Sciences Humans Male Molecular modelling multidisciplinary Proteomics Rheumatic heart disease Science Stenosis Surgeons Western blotting
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