Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates

Acetylcholinesterase (AChE) that has been covalently inhibited by organophosphate compounds (OPCs), such as nerve agents and pesticides, has traditionally been reactivated by using nucleophilic oximes. There is, however, a clearly recognized need for new classes of compounds with the ability to reac...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2015-10, Vol.16 (15), p.2205-2215
Hauptverfasser:	Katz, Francine S., Pecic, Stevan, Tran, Timothy H., Trakht, Ilya, Schneider, Laura, Zhu, Zhengxiang, Ton-That, Long, Luzac, Michal, Zlatanic, Viktor, Damera, Shivani, Macdonald, Joanne, Landry, Donald W., Tong, Liang, Stojanovic, Milan N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Dose-Response Relationship, Drug Drug Discovery Enzyme Activation - drug effects high-throughput screening INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY medicinal chemistry Molecular Structure neurological agents Organophosphates - chemical synthesis Organophosphates - chemistry Organophosphates - pharmacology Phenols - chemistry Structure-Activity Relationship structure-activity relationships
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