2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

We discovered recently that the central metabolite α-ketoglutarate (α-KG) extends the lifespan of C. elegans through inhibition of ATP synthase and TOR signaling. Here we find, unexpectedly, that (R)-2-hydroxyglutarate ((R)-2HG), an oncometabolite that interferes with various α-KG-mediated processes...

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Veröffentlicht in:	Cell metabolism 2015-09, Vol.22 (3), p.508-515
Hauptverfasser:	Fu, Xudong, Chin, Randall M., Vergnes, Laurent, Hwang, Heejun, Deng, Gang, Xing, Yanpeng, Pai, Melody Y., Li, Sichen, Ta, Lisa, Fazlollahi, Farbod, Chen, Chuo, Prins, Robert M., Teitell, Michael A., Nathanson, David A., Lai, Albert, Faull, Kym F., Jiang, Meisheng, Clarke, Steven G., Cloughesy, Timothy F., Graeber, Thomas G., Braas, Daniel, Christofk, Heather R., Jung, Michael E., Reue, Karen, Huang, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Animals Caenorhabditis elegans - physiology Cell Proliferation Glioblastoma - genetics Glioblastoma - metabolism Glutarates - metabolism Humans Isocitrate Dehydrogenase - genetics Isocitrate Dehydrogenase - metabolism Longevity Mutation Signal Transduction TOR Serine-Threonine Kinases - metabolism
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