Deubiquitinases Modulate Platelet Proteome Ubiquitination, Aggregation, and Thrombosis

OBJECTIVE—Platelets express a functional ubiquitin–proteasome system. Mass spectrometry shows that platelets contain several deubiquitinases, but whether these are functional, modulate the proteome, or affect platelet reactivity are unknown. APPROACH AND RESULTS—Platelet lysates contained ubiquitin–...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2015-12, Vol.35 (12), p.2657-2666
Hauptverfasser:	Gupta, Nilaksh, Li, Wei, McIntyre, Thomas M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyridines - pharmacology Animals Benzoates - pharmacology Blood Platelets - drug effects Blood Platelets - enzymology Chlorides Disease Models, Animal Enzyme Inhibitors - pharmacology Ferric Compounds Furans Humans Mice, Inbred C57BL Microfluidic Analytical Techniques Microscopy, Interference Piperidones - pharmacology Platelet Aggregation - drug effects Platelet Function Tests Platelet Glycoprotein GPIIb-IIIa Complex - metabolism Proteasome Endopeptidase Complex - blood Pyrazoles - pharmacology Receptors, Collagen - blood Receptors, Thrombin - blood Signal Transduction Thiocyanates - pharmacology Thrombosis - blood Thrombosis - chemically induced Thrombosis - enzymology Thrombosis - prevention & control Ubiquitin Thiolesterase - antagonists & inhibitors Ubiquitin Thiolesterase - blood Ubiquitin-Specific Proteases - antagonists & inhibitors Ubiquitin-Specific Proteases - blood Ubiquitination
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