Mucin1 promotes the migration and invasion of hepatocellular carcinoma cells via JNK-mediated phosphorylation of Smad2 at the C-terminal and linker regions

Mucin1 (MUC1), as an oncogene, plays a key role in the progression and tumorigenesis of many human adenocarcinomas. In this study, wound-healing, transwell migration and matrigel invasion assays showed that MUC1 promotes human hepatocellular carcinoma (HCC) cell migration and invasion by MUC1 gene s...

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Veröffentlicht in:	Oncotarget 2015-08, Vol.6 (22), p.19264-19278
Hauptverfasser:	Wang, Juan, Liu, Guomu, Li, Qiongshu, Wang, Fang, Xie, Fei, Zhai, Ruiping, Guo, Yingying, Chen, Tanxiu, Zhang, Nannan, Ni, Weihua, Yuan, Hongyan, Tai, Guixiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Movement - physiology Hep G2 Cells Humans Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology MAP Kinase Signaling System Mucin-1 - genetics Mucin-1 - metabolism Phosphorylation Research Paper Smad2 Protein - genetics Smad2 Protein - metabolism Transfection
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