Underexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is a rare and highly aggressive malignancy. In this study, we identified the presence of gene deletion and missense mutation leading to inactivation or underexpression of liver kinase B1 (LKB1) tumor suppressor and excluded the involvement of LKB1 gene hypermeth...

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Veröffentlicht in:	Oncotarget 2015-08, Vol.6 (22), p.18905-18920
Hauptverfasser:	Wang, Jinghan, Zhang, Keqiang, Wang, Jinhui, Wu, Xiwei, Liu, Xiyong, Li, Bin, Zhu, Yan, Yu, Yong, Cheng, Qingbao, Hu, Zhenli, Guo, Chao, Hu, Shuya, Mu, Bing, Tsai, Chun-Hao, Li, Jie, Smith, Lynne, Yang, Lu, Liu, Qi, Chu, Peiguo, Chang, Vincent, Zhang, Baihe, Wu, Mengchao, Jiang, Xiaoqing, Yen, Yun
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence beta Catenin - metabolism Bile Duct Neoplasms - enzymology Bile Duct Neoplasms - genetics Bile Duct Neoplasms - metabolism Bile Duct Neoplasms - pathology Cell Growth Processes - physiology Cell Line, Tumor Cell Movement - physiology Cholangiocarcinoma - enzymology Cholangiocarcinoma - genetics Cholangiocarcinoma - metabolism Cholangiocarcinoma - pathology DNA Methylation Down-Regulation Female Gene Knockdown Techniques Genes, Tumor Suppressor Humans Male Middle Aged Molecular Sequence Data Protein-Serine-Threonine Kinases - biosynthesis Protein-Serine-Threonine Kinases - metabolism Research Paper Wnt Signaling Pathway
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