Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis

Sepsis is an exaggerated and dysfunctional immune response to infection. Activation of innate immunity recognition systems including complement and the Toll-like receptor family initiate this disproportionate inflammatory response. The aim of this study was to explore the effect of combined inhibiti...

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Veröffentlicht in:	Critical care (London, England) England), 2015-11, Vol.19 (1), p.415-415, Article 415
Hauptverfasser:	Skjeflo, Espen W, Sagatun, Caroline, Dybwik, Knut, Aam, Sturla, Urving, Sven H, Nunn, Miles A, Fure, Hilde, Lau, Corinna, Brekke, Ole-Lars, Huber-Lang, Markus, Espevik, Terje, Barratt-Due, Andreas, Nielsen, Erik W, Mollnes, Tom E
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Clinical medical disciplines: 750 Complement C5 - antagonists & inhibitors Critical care Cytokines Enzymes Epidemiology Infection Inflammation Inflammation - blood Inflammation - mortality Klinisk medisinske fag: 750 Laboratories Lipopolysaccharide Receptors - metabolism Medical disciplines: 700 Medical prognosis Medisinske Fag: 700 Multiple organ dysfunction syndrome Neutrophils Patient outcomes Pulmonary arteries Rodents Sepsis Sepsis - drug therapy Sepsis - metabolism Sepsis - microbiology Sepsis - mortality Swine Toll-Like Receptors - immunology Toll-Like Receptors - metabolism Tumor necrosis factor-TNF VDP
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