Cell surface glycoengineering improves selectin-mediated adhesion of mesenchymal stem cells (MSCs) and cardiosphere-derived cells (CDCs): Pilot validation in porcine ischemia-reperfusion model

Abstract Promising results are emerging in clinical trials focused on stem cell therapy for cardiology applications. However, the low homing and engraftment of the injected cells to target tissue continues to be a problem. Cellular glycoengineering can address this limitation by enabling the targeti...

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Veröffentlicht in:	Biomaterials 2016-01, Vol.74, p.19-30
Hauptverfasser:	Lo, Chi Y, Weil, Brian R, Palka, Beth A, Momeni, Arezoo, Canty, John M, Neelamegham, Sriram
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion Adhesion molecule Advanced Basic Science Animals Blood flow Cell adhesion Cell Adhesion - physiology Cell Membrane - metabolism cell proliferation Cells, Cultured Cellular clinical trials Dentistry Disease Models, Animal endothelial cells Fucosyltransferases - metabolism glycoproteins Glycoproteins - metabolism heart Homing inflammation Injury prevention Joining Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Myocytes, Cardiac - cytology palmitic acid Pilot Projects Pilots PSGL-1 Recombinant Recombinant protein Reperfusion Injury - therapy Selectin Selectins - physiology Shear Sialyl Lewis-X Stem cells Swine therapeutics
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