HIV-1 Tat protein enhances the intracellular growth of Leishmania amazonensis via the ds-RNA induced protein PKR

HIV-1 co-infection with human parasitic diseases is a growing public health problem worldwide. Leishmania parasites infect and replicate inside macrophages, thereby subverting host signaling pathways, including the response mediated by PKR. The HIV-1 Tat protein interacts with PKR and plays a pivota...

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Veröffentlicht in:	Scientific reports 2015-11, Vol.5 (1), p.16777-16777, Article 16777
Hauptverfasser:	Vivarini, Áislan de Carvalho, Santos Pereira, Renata de Meirelles, Barreto-de-Souza, Victor, Temerozo, Jairo Ramos, Soares, Deivid C., Saraiva, Elvira M., Saliba, Alessandra Mattos, Bou-Habib, Dumith Chequer, Lopes, Ulisses Gazos
Format:	Artikel
Sprache:	eng
Schlagworte:	38 38/1 38/109 38/77 631/326/88 692/420/254 96 96/1 Cell Line eIF-2 Kinase - metabolism Enzyme Activation HIV-1 - metabolism Humanities and Social Sciences Humans Interleukin-10 - metabolism Intracellular Space - parasitology Leishmania - growth & development Leishmania - metabolism Leishmaniasis - metabolism Leishmaniasis - parasitology Leishmaniasis - pathology Macrophages - enzymology Macrophages - parasitology multidisciplinary NF-kappa B - metabolism Nitric Oxide Synthase Type II - metabolism Protein Structure, Tertiary RNA, Double-Stranded - metabolism Science Signal Transduction tat Gene Products, Human Immunodeficiency Virus - chemistry tat Gene Products, Human Immunodeficiency Virus - metabolism
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