Estrogen reduces CCL4- induced liver fibrosis in rats
Chronic liver diseases, such as fibrosis or cirrhosis, are more common in men than in women. This gender difference may be related to the effects of sex hormones on the liver. The aim of the present work was to investigate the effects of estrogen on CCL(4)-induced fibrosis of the liver in rats. Live...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2002-10, Vol.8 (5), p.883-887 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Xu, Jun-Wang Gong, Jun Chang, Xin-Ming Luo, Jin-Yan Dong, Lei Hao, Zhi-Ming Jia, Ai Xu, Gui-Ping |
| description | Chronic liver diseases, such as fibrosis or cirrhosis, are more common in men than in women. This gender difference may be related to the effects of sex hormones on the liver. The aim of the present work was to investigate the effects of estrogen on CCL(4)-induced fibrosis of the liver in rats.
Liver fibrosis was induced in male, female and ovariectomized rats by CCL(4) administration. All the groups were treated with estradiol(1 mg/kg) twice weekly. And tamoxifen was given to male fibrosis model. At the end of 8 weeks, all the rats were killed to study serum indicators and the livers.
Estradiol treatment reduced aspartate aminotransferase(AST), alanine aminotransferase (ALT), hyaluronic acid(HA) and type IV collagen(CIV) in sera, suppressed hepatic collagen content, decreased the areas of hepatic stellate cells (HSC) positive for alpha-smooth muscle actin (alpha-SMA), and lowered the synthesis of hepatic type I collagen significantly in both sexes and ovariectomy fibrotic rats induced by CCL(4) administration. Whereas, tamoxifen had the opposite effect. The fibrotic response of the female liver to CCL(4) treatment was significantly weaker than that of male liver.
Estradiol reduces CCL(4)-induced hepatic fibrosis in rats. The antifibrogenic role of estrogen in the liver may be one reason for the sex associated differences in the progression from hepatic fibrosis to cirrhosis. |
| doi_str_mv | 10.3748/wjg.v8.i5.883 |
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Liver fibrosis was induced in male, female and ovariectomized rats by CCL(4) administration. All the groups were treated with estradiol(1 mg/kg) twice weekly. And tamoxifen was given to male fibrosis model. At the end of 8 weeks, all the rats were killed to study serum indicators and the livers.
Estradiol treatment reduced aspartate aminotransferase(AST), alanine aminotransferase (ALT), hyaluronic acid(HA) and type IV collagen(CIV) in sera, suppressed hepatic collagen content, decreased the areas of hepatic stellate cells (HSC) positive for alpha-smooth muscle actin (alpha-SMA), and lowered the synthesis of hepatic type I collagen significantly in both sexes and ovariectomy fibrotic rats induced by CCL(4) administration. Whereas, tamoxifen had the opposite effect. The fibrotic response of the female liver to CCL(4) treatment was significantly weaker than that of male liver.
Estradiol reduces CCL(4)-induced hepatic fibrosis in rats. The antifibrogenic role of estrogen in the liver may be one reason for the sex associated differences in the progression from hepatic fibrosis to cirrhosis.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v8.i5.883</identifier><identifier>PMID: 12378635</identifier><language>eng</language><publisher>United States: Department of Gastroenterology, Second Hospital of Xi'an Jiaotong University,Xi'an 710031,Shaanxi Province,China%Department of Gastroenterology, First Hospital of Xi'an Jiaotong University,Xi'an 710061,Shaanxi Province, China</publisher><subject>Actins - analysis ; Alanine Transaminase - blood ; Animals ; Antioxidants - metabolism ; Aspartate Aminotransferases - blood ; Basic Research ; Biomarkers ; Carbon Tetrachloride ; Collagen Type I - analysis ; Estrogen Antagonists - pharmacology ; Estrogens - pharmacology ; Female ; Liver - chemistry ; Liver - metabolism ; Liver - pathology ; Liver Cirrhosis - chemically induced ; Liver Cirrhosis - drug therapy ; Liver Cirrhosis - pathology ; Male ; Platelet-Derived Growth Factor - analysis ; Rats ; Rats, Sprague-Dawley ; Tamoxifen - pharmacology ; Transforming Growth Factor beta - analysis ; Transforming Growth Factor beta1</subject><ispartof>World journal of gastroenterology : WJG, 2002-10, Vol.8 (5), p.883-887</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>The Author(s) 2002. Published by Baishideng Publishing Group Inc. All rights reserved. 2002</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/wjg/wjg.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656580/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656580/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12378635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Jun-Wang</creatorcontrib><creatorcontrib>Gong, Jun</creatorcontrib><creatorcontrib>Chang, Xin-Ming</creatorcontrib><creatorcontrib>Luo, Jin-Yan</creatorcontrib><creatorcontrib>Dong, Lei</creatorcontrib><creatorcontrib>Hao, Zhi-Ming</creatorcontrib><creatorcontrib>Jia, Ai</creatorcontrib><creatorcontrib>Xu, Gui-Ping</creatorcontrib><title>Estrogen reduces CCL4- induced liver fibrosis in rats</title><title>World journal of gastroenterology : WJG</title><addtitle>World J Gastroenterol</addtitle><description>Chronic liver diseases, such as fibrosis or cirrhosis, are more common in men than in women. This gender difference may be related to the effects of sex hormones on the liver. The aim of the present work was to investigate the effects of estrogen on CCL(4)-induced fibrosis of the liver in rats.
Liver fibrosis was induced in male, female and ovariectomized rats by CCL(4) administration. All the groups were treated with estradiol(1 mg/kg) twice weekly. And tamoxifen was given to male fibrosis model. At the end of 8 weeks, all the rats were killed to study serum indicators and the livers.
Estradiol treatment reduced aspartate aminotransferase(AST), alanine aminotransferase (ALT), hyaluronic acid(HA) and type IV collagen(CIV) in sera, suppressed hepatic collagen content, decreased the areas of hepatic stellate cells (HSC) positive for alpha-smooth muscle actin (alpha-SMA), and lowered the synthesis of hepatic type I collagen significantly in both sexes and ovariectomy fibrotic rats induced by CCL(4) administration. Whereas, tamoxifen had the opposite effect. The fibrotic response of the female liver to CCL(4) treatment was significantly weaker than that of male liver.
Estradiol reduces CCL(4)-induced hepatic fibrosis in rats. The antifibrogenic role of estrogen in the liver may be one reason for the sex associated differences in the progression from hepatic fibrosis to cirrhosis.</description><subject>Actins - analysis</subject><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Basic Research</subject><subject>Biomarkers</subject><subject>Carbon Tetrachloride</subject><subject>Collagen Type I - analysis</subject><subject>Estrogen Antagonists - pharmacology</subject><subject>Estrogens - pharmacology</subject><subject>Female</subject><subject>Liver - chemistry</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver Cirrhosis - chemically induced</subject><subject>Liver Cirrhosis - drug therapy</subject><subject>Liver Cirrhosis - pathology</subject><subject>Male</subject><subject>Platelet-Derived Growth Factor - analysis</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Tamoxifen - pharmacology</subject><subject>Transforming Growth Factor beta - analysis</subject><subject>Transforming Growth Factor beta1</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1Lw0AQhhdRbK0evUoOXhN3Z_arF0FC_YCCFz2HTXYTt7RJ2U1a_PemVEVPw8wLzzs8hFwzmqHi-m6_arKdzrzItMYTMgVg8xQ0p6dkyihV6RxBTchFjCtKAVHAOZkwQKUliikRi9iHrnFtEpwdKheTPF_yNPHtYbPJ2u9cSGpfhi76OJ6TYPp4Sc5qs47u6nvOyPvj4i1_TpevTy_5wzLdAmCfImrLNFeGVnKsY4rbEmprBAPBRVWjBAbOSgMUa2mUErbSXGNpOK_lXOCM3B-526HcOFu5tg9mXWyD35jwWXTGF_-T1n8UTbcruBRSaDoCbo-AvWlr0zbFqhtCO75cjN5gFELFQcqM3Pzt-S348YRfpAVpKQ</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Xu, Jun-Wang</creator><creator>Gong, Jun</creator><creator>Chang, Xin-Ming</creator><creator>Luo, Jin-Yan</creator><creator>Dong, Lei</creator><creator>Hao, Zhi-Ming</creator><creator>Jia, Ai</creator><creator>Xu, Gui-Ping</creator><general>Department of Gastroenterology, Second Hospital of Xi'an Jiaotong University,Xi'an 710031,Shaanxi Province,China%Department of Gastroenterology, First Hospital of Xi'an Jiaotong University,Xi'an 710061,Shaanxi Province, China</general><general>Baishideng Publishing Group Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20021001</creationdate><title>Estrogen reduces CCL4- induced liver fibrosis in rats</title><author>Xu, Jun-Wang ; Gong, Jun ; Chang, Xin-Ming ; Luo, Jin-Yan ; Dong, Lei ; Hao, Zhi-Ming ; Jia, Ai ; Xu, Gui-Ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p223t-338d1847a0c6863174db2fda512545cf36212ed6a203f6a775dc8483ba44f6953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Actins - analysis</topic><topic>Alanine Transaminase - blood</topic><topic>Animals</topic><topic>Antioxidants - metabolism</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Basic Research</topic><topic>Biomarkers</topic><topic>Carbon Tetrachloride</topic><topic>Collagen Type I - analysis</topic><topic>Estrogen Antagonists - pharmacology</topic><topic>Estrogens - pharmacology</topic><topic>Female</topic><topic>Liver - chemistry</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver Cirrhosis - chemically induced</topic><topic>Liver Cirrhosis - drug therapy</topic><topic>Liver Cirrhosis - pathology</topic><topic>Male</topic><topic>Platelet-Derived Growth Factor - analysis</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Tamoxifen - pharmacology</topic><topic>Transforming Growth Factor beta - analysis</topic><topic>Transforming Growth Factor beta1</topic><toplevel>online_resources</toplevel><creatorcontrib>Xu, Jun-Wang</creatorcontrib><creatorcontrib>Gong, Jun</creatorcontrib><creatorcontrib>Chang, Xin-Ming</creatorcontrib><creatorcontrib>Luo, Jin-Yan</creatorcontrib><creatorcontrib>Dong, Lei</creatorcontrib><creatorcontrib>Hao, Zhi-Ming</creatorcontrib><creatorcontrib>Jia, Ai</creatorcontrib><creatorcontrib>Xu, Gui-Ping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Jun-Wang</au><au>Gong, Jun</au><au>Chang, Xin-Ming</au><au>Luo, Jin-Yan</au><au>Dong, Lei</au><au>Hao, Zhi-Ming</au><au>Jia, Ai</au><au>Xu, Gui-Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estrogen reduces CCL4- induced liver fibrosis in rats</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World J Gastroenterol</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>8</volume><issue>5</issue><spage>883</spage><epage>887</epage><pages>883-887</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>Chronic liver diseases, such as fibrosis or cirrhosis, are more common in men than in women. This gender difference may be related to the effects of sex hormones on the liver. The aim of the present work was to investigate the effects of estrogen on CCL(4)-induced fibrosis of the liver in rats.
Liver fibrosis was induced in male, female and ovariectomized rats by CCL(4) administration. All the groups were treated with estradiol(1 mg/kg) twice weekly. And tamoxifen was given to male fibrosis model. At the end of 8 weeks, all the rats were killed to study serum indicators and the livers.
Estradiol treatment reduced aspartate aminotransferase(AST), alanine aminotransferase (ALT), hyaluronic acid(HA) and type IV collagen(CIV) in sera, suppressed hepatic collagen content, decreased the areas of hepatic stellate cells (HSC) positive for alpha-smooth muscle actin (alpha-SMA), and lowered the synthesis of hepatic type I collagen significantly in both sexes and ovariectomy fibrotic rats induced by CCL(4) administration. Whereas, tamoxifen had the opposite effect. The fibrotic response of the female liver to CCL(4) treatment was significantly weaker than that of male liver.
Estradiol reduces CCL(4)-induced hepatic fibrosis in rats. The antifibrogenic role of estrogen in the liver may be one reason for the sex associated differences in the progression from hepatic fibrosis to cirrhosis.</abstract><cop>United States</cop><pub>Department of Gastroenterology, Second Hospital of Xi'an Jiaotong University,Xi'an 710031,Shaanxi Province,China%Department of Gastroenterology, First Hospital of Xi'an Jiaotong University,Xi'an 710061,Shaanxi Province, China</pub><pmid>12378635</pmid><doi>10.3748/wjg.v8.i5.883</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | World journal of gastroenterology : WJG, 2002-10, Vol.8 (5), p.883-887 |
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| language | eng |
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| source | MEDLINE; PubMed Central; Alma/SFX Local Collection |
| subjects | Actins - analysis Alanine Transaminase - blood Animals Antioxidants - metabolism Aspartate Aminotransferases - blood Basic Research Biomarkers Carbon Tetrachloride Collagen Type I - analysis Estrogen Antagonists - pharmacology Estrogens - pharmacology Female Liver - chemistry Liver - metabolism Liver - pathology Liver Cirrhosis - chemically induced Liver Cirrhosis - drug therapy Liver Cirrhosis - pathology Male Platelet-Derived Growth Factor - analysis Rats Rats, Sprague-Dawley Tamoxifen - pharmacology Transforming Growth Factor beta - analysis Transforming Growth Factor beta1 |
| title | Estrogen reduces CCL4- induced liver fibrosis in rats |
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