Angiotensin II Downregulates MicroRNA-145 to Regulate Kruppel-like Factor 4 and Myocardin Expression in Human Coronary Arterial Smooth Muscle Cells under High Glucose Conditions

MicroRNA (miR)-145 is the most abundant miR in vascular smooth muscle cells (VSMCs). However, the effect of hyperglycemia on the regulation of miR-145 is unknown. We hypothesized that the hyperglycemic condition activates a proinflammatory response that mediates the expression of miR-145 in VSMCs. W...

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Veröffentlicht in:	Molecular medicine (Cambridge, Mass.) Mass.), 2015-07, Vol.21 (1), p.616-625
Hauptverfasser:	Shyu, Kou-Gi, Cheng, Wen-Ping, Wang, Bao-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - genetics Animals Antibodies Carotid arteries Catheters Cell growth Cell Proliferation - drug effects Cells, Cultured Coronary vessels Coronary Vessels - drug effects Coronary Vessels - pathology Diabetes Enzymes Gene expression Gene Expression Regulation - drug effects Glucose Glucose - pharmacology Humans Hyperglycemia Insulin resistance Kruppel-Like Transcription Factors - biosynthesis Laboratory animals MicroRNAs MicroRNAs - biosynthesis MicroRNAs - genetics Muscle, Smooth, Vascular Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - pathology Nuclear Proteins - biosynthesis Pathogenesis Polymerase chain reaction Rats Smooth muscle Trans-Activators - biosynthesis Tunica Media - metabolism Tunica Media - pathology Valsartan - administration & dosage Variance analysis Vectors (Biology) Veins & arteries
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